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EnglishCentromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer.
Barra, V., & Fachinetti, D. (2018). The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA.
| Data di pubblicazione: | 2018 |
| Titolo: | The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA |
| Autori: | |
| Citazione: | Barra, V., & Fachinetti, D. (2018). The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/s41467-018-06545-y |
| Abstract: | Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer. |
| URL: | http://www.nature.com/ncomms/index.html |
| Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica |
| Appare nelle tipologie: | 1.09 Review essay (rassegna critica) |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| s41467-018-06545-y.pdf | Review | Versione Editoriale | Open Access Visualizza/Apri |
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