Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.
EnglishCentromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer.
Barra, V., & Fachinetti, D. (2018). The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA.
| Data di pubblicazione: | 2018 |
| Titolo: | The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA |
| Autori: | |
| Citazione: | Barra, V., & Fachinetti, D. (2018). The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/s41467-018-06545-y |
| Abstract: | Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer. |
| URL: | http://www.nature.com/ncomms/index.html |
| Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica |
| Appare nelle tipologie: | 1.09 Review essay (rassegna critica) |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| s41467-018-06545-y.pdf | Review | Versione Editoriale | Open Access Visualizza/Apri |
Copyright © 2020