Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer.

Barra V., Fachinetti D. (2018). The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA [10.1038/s41467-018-06545-y].

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

Barra V.;
2018-12-01

Abstract

Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer.
Settore BIO/18 - Genetica
https://www.nature.com/articles/s41467-018-06545-y#article-info
http://www.nature.com/ncomms/index.html
Barra V., Fachinetti D. (2018). The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA [10.1038/s41467-018-06545-y].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/391385
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