Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer.
Barra V., & Fachinetti D. (2018). The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA [10.1038/s41467-018-06545-y].
Data di pubblicazione: | 2018-12-01 | |
Titolo: | The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA | |
Autori: | ||
Citazione: | Barra V., & Fachinetti D. (2018). The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA [10.1038/s41467-018-06545-y]. | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/s41467-018-06545-y | |
Abstract: | Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer. | |
URL dell'editore: | https://www.nature.com/articles/s41467-018-06545-y#article-info | |
URL: | http://www.nature.com/ncomms/index.html | |
Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica | |
Appare nelle tipologie: | 1.09 Review essay (rassegna critica) |
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