An identification procedure for biological systems cast as quasi-species models is proposed. Their identification is a challenging problem because of the bilinear dependence on the parameters and their physical constraints. The proposed solution is within the framework of set-membership identification. %The bilinear dependence on parameters of the model and their physical constraints make the present issue challenging. We determine an estimate of the model parameters together with their interval of variability (Uncertainty Intervals), taking into account all the physical constraints. Invalidation/validation is performed on the basis of the predictive capability of the estimated models. The effectiveness of the proposed procedure has been illustrated by means of simulation experiments.

Falugi, P., Giarré, L. (2009). Identification and validation of quasispecies models for biological systems. SYSTEMS & CONTROL LETTERS, 58(7), 529-539 [http://dx.doi.org/10.1016/j.sysconle.2009.03.005].

Identification and validation of quasispecies models for biological systems

GIARRE, Laura
2009-01-01

Abstract

An identification procedure for biological systems cast as quasi-species models is proposed. Their identification is a challenging problem because of the bilinear dependence on the parameters and their physical constraints. The proposed solution is within the framework of set-membership identification. %The bilinear dependence on parameters of the model and their physical constraints make the present issue challenging. We determine an estimate of the model parameters together with their interval of variability (Uncertainty Intervals), taking into account all the physical constraints. Invalidation/validation is performed on the basis of the predictive capability of the estimated models. The effectiveness of the proposed procedure has been illustrated by means of simulation experiments.
2009
Falugi, P., Giarré, L. (2009). Identification and validation of quasispecies models for biological systems. SYSTEMS & CONTROL LETTERS, 58(7), 529-539 [http://dx.doi.org/10.1016/j.sysconle.2009.03.005].
File in questo prodotto:
File Dimensione Formato  
39009.pdf

Solo gestori archvio

Dimensione 2.28 MB
Formato Adobe PDF
2.28 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/39009
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact