Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.
CIOFFI, G., DAL PIAZ, F., VASSALLO, A., VENTURELLA, F., DE CAPRARIIS, P., DE SIMONE, F., et al. (2008). Antiproliferative Oleanane Saponins from Meryta denhamii. JOURNAL OF NATURAL PRODUCTS, 71, 1000-1004 [10.1021/np8000464].
Antiproliferative Oleanane Saponins from Meryta denhamii
VASSALLO, Antonio;VENTURELLA, Fabio;DE SIMONE, Francesco;
2008-01-01
Abstract
Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.
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