Lomitapide (Juxtapid® in US and Lojuxta® in Europe) is the first developed inhibitor of the microsomal triglyceride transfer protein (MTP) approved as a novel drug for the management of homozygous familial hypercholesterolemia (HoFH). It acts by binding directly and selectively to MTP thus decreasing the assembly and secretion of the apo-B containing lipoproteins both in the liver and in the intestine.
Giammanco, A., Cefalù, A.B., Noto, D., & Averna, M. (2020). Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide. CURRENT MEDICINAL CHEMISTRY, 27(23), 3773-3783 [10.2174/0929867326666190121120735].
Data di pubblicazione: | 2020 | |
Titolo: | Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide | |
Autori: | ||
Citazione: | Giammanco, A., Cefalù, A.B., Noto, D., & Averna, M. (2020). Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide. CURRENT MEDICINAL CHEMISTRY, 27(23), 3773-3783 [10.2174/0929867326666190121120735]. | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.2174/0929867326666190121120735 | |
Abstract: | Lomitapide (Juxtapid® in US and Lojuxta® in Europe) is the first developed inhibitor of the microsomal triglyceride transfer protein (MTP) approved as a novel drug for the management of homozygous familial hypercholesterolemia (HoFH). It acts by binding directly and selectively to MTP thus decreasing the assembly and secretion of the apo-B containing lipoproteins both in the liver and in the intestine. | |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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