Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

Grimaudo, S; Pipitone, RM; Pennisi, G; Celsa, C; Cammà, C; Di Marco, V; Barcellona, MR; Boemi, R; Enea, M; Giannetti, A; Spatola, F; Marchesini, G; Craxì, A; Petta, S

doi:10.1016/j.cgh.2019.08.011

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Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.

Data di pubblicazione:	2019
Titolo:	Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease
Autori:	GRIMAUDO, Stefania PIPITONE, Rosaria Maria PENNISI, Grazia CELSA, Ciro CAMMA', Calogero DI MARCO, Vito BARCELLONA, Maria Rosa BOEMI, Roberta ENEA, Marco GIANNETTI, Aurora SPATOLA, Federica Marchesini, Giulio CRAXI, Antonio PETTA, Salvatore mostra contributor esterni nascondi contributor esterni
Citazione:	Grimaudo, S., Pipitone, R., Pennisi, G., Celsa, C., Cammà, C., Di Marco, V., et al. (2019). Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY.
Rivista:	CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Digital Object Identifier (DOI):	10.1016/j.cgh.2019.08.011
Abstract:	Patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk for liver-related complications, such as decompensation, hepatocellular carcinoma (HCC), and death; the severity of liver fibrosis and metabolic comorbidities are the main risk factors. A single nucleotide polymorphism in patatin-like phospholipase domain-containing-3 (PNPLA3) gene is associated with higher prevalence of liver damage and HCC, but there are no data from prospective studies of outcomes of patients with this polymorphism. We investigated whether the common rs738409 variant in PNPLA3 gene associates with the occurrence of liver-related events and death in a large cohort of patients with NAFLD.
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