We evaluated liposomal amphotericin B (AmBisome; Vestar, San Dimas, CA) administered to 88 immunocompetent patients (56 children) with visceral leishmaniasis (VL) caused by Leishmania infantum. Thirteen patients received 4 mg/kg on days 1-5 and 10 (total dose, 24 mg/kg), and all were cured; 42 received 3 mg/kg on days 1-5 and 10 (18 mg/kg), and 41 were cured; 32 received 3 mg/kg on days 1-4 and 10 (15 mg/kg), and 29 were cured (amastigotes were not cleared from 1 child, and 2 relapsed). One adult was cured with a total dose of 12mg/kg. The four children who were not cured received 3 mg/kg for 10 days; none had further relapses. There were no significant adverse events. For VL due to L. infantum, we recommended a total dose of AmBisome of > or = 20 mg/kg, given in > or = 5 doses of 3-4 mg/kg over > or = 10 days.

DAVIDSON R.N, DI MARTINO L, GRADONI L, GIACCHINO R, GAETA GB, PEMPINELLO R, et al. (1996). SHORT COURSE TREATMENT OF VISCERAL LEISHMANIASIS WITH LIPOSOMAL AMPHOTERICIN B (AmBisome). CLINICAL INFECTIOUS DISEASES, 22, 938-943 [10.1093/clinids/22.6.938].

SHORT COURSE TREATMENT OF VISCERAL LEISHMANIASIS WITH LIPOSOMAL AMPHOTERICIN B (AmBisome)

A. CASCIO;
1996-01-01

Abstract

We evaluated liposomal amphotericin B (AmBisome; Vestar, San Dimas, CA) administered to 88 immunocompetent patients (56 children) with visceral leishmaniasis (VL) caused by Leishmania infantum. Thirteen patients received 4 mg/kg on days 1-5 and 10 (total dose, 24 mg/kg), and all were cured; 42 received 3 mg/kg on days 1-5 and 10 (18 mg/kg), and 41 were cured; 32 received 3 mg/kg on days 1-4 and 10 (15 mg/kg), and 29 were cured (amastigotes were not cleared from 1 child, and 2 relapsed). One adult was cured with a total dose of 12mg/kg. The four children who were not cured received 3 mg/kg for 10 days; none had further relapses. There were no significant adverse events. For VL due to L. infantum, we recommended a total dose of AmBisome of > or = 20 mg/kg, given in > or = 5 doses of 3-4 mg/kg over > or = 10 days.
DAVIDSON R.N, DI MARTINO L, GRADONI L, GIACCHINO R, GAETA GB, PEMPINELLO R, et al. (1996). SHORT COURSE TREATMENT OF VISCERAL LEISHMANIASIS WITH LIPOSOMAL AMPHOTERICIN B (AmBisome). CLINICAL INFECTIOUS DISEASES, 22, 938-943 [10.1093/clinids/22.6.938].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/384845
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