Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6. Copyright © 2009 John Wiley & Sons, Ltd.
Rosselli, S., Maggio, A.M., Bruno, M., Spadaro, V., Formisano, C., Irace, C., et al. (2009). Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius. PHYTOTHERAPY RESEARCH, 23, 1243-1249 [10.1002/ptr.2569].
Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius
ROSSELLI, Sergio;MAGGIO, Antonella Maria;BRUNO, Maurizio;SPADARO, Vivienne;
2009-01-01
Abstract
Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6. Copyright © 2009 John Wiley & Sons, Ltd.
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