Gut microbiota is involved in gastrointestinal carcinogenesis. Also, it modulates the activity, efficacy and toxicity of several chemotherapy agents, such as gemcitabine, cyclophosphamide, irinotecan, cisplatin and 5-Fluorouracil, and target therapy, such as tyrosine kinase inhibitors. More recently, accumulating data suggest that the composition of gut microbiota may also affect efficacy and toxicity of cancer immunotherapy. Therefore, the manipulation of gut microbiota through antibiotics, probiotics, prebiotics or fecal transplantation has been investigating with the aim to improve efficacy and mitigate toxicity of anticancer drugs.

Gori S., Inno A., Belluomini L., Bocus P., Bisoffi Z., Russo A., et al. (2019). Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 143, 139-147 [10.1016/j.critrevonc.2019.09.003].

Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy

Russo A.
;
2019-01-01

Abstract

Gut microbiota is involved in gastrointestinal carcinogenesis. Also, it modulates the activity, efficacy and toxicity of several chemotherapy agents, such as gemcitabine, cyclophosphamide, irinotecan, cisplatin and 5-Fluorouracil, and target therapy, such as tyrosine kinase inhibitors. More recently, accumulating data suggest that the composition of gut microbiota may also affect efficacy and toxicity of cancer immunotherapy. Therefore, the manipulation of gut microbiota through antibiotics, probiotics, prebiotics or fecal transplantation has been investigating with the aim to improve efficacy and mitigate toxicity of anticancer drugs.
Settore MED/06 - Oncologia Medica
Gori S., Inno A., Belluomini L., Bocus P., Bisoffi Z., Russo A., et al. (2019). Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 143, 139-147 [10.1016/j.critrevonc.2019.09.003].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/383569
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