Improving healthspan is the main objective of anti-ageing research. Currently, innovative gene therapy-based approaches seem to be among the most promising for preventing and treating chronic polygenic pathologies, including age-related ones. The gene-based therapy allows to modulate the genome architecture using both direct (e.g., by gene editing) and indirect (e.g., by viral or non-viral vectors) approaches. Nevertheless, considering the extraordinary complexity of processes involved in ageing and ageing-related diseases, the effectiveness of these therapeutic options is often unsatisfactory and limited by their side-effects. Thus, clinical implementation of such applications is certainly a long-time process that will require many translation phases for addressing challenges. However, after overcoming these issues, their implementation in clinical practice may obviously provide new possibilities in anti-ageing medicine. Here, we review and discuss recent advances in this rapidly developing research field.

Vaiserman, A., De Falco, E., Koliada, A., Maslova, O., Balistreri, C.R. (2019). Anti-Ageing Gene Therapy: Not so Far Away?. AGEING RESEARCH REVIEWS, 56, 100977-100987 [10.1016/j.arr.2019.100977].

Anti-Ageing Gene Therapy: Not so Far Away?

Balistreri, Carmela Rita
Project Administration
2019-01-01

Abstract

Improving healthspan is the main objective of anti-ageing research. Currently, innovative gene therapy-based approaches seem to be among the most promising for preventing and treating chronic polygenic pathologies, including age-related ones. The gene-based therapy allows to modulate the genome architecture using both direct (e.g., by gene editing) and indirect (e.g., by viral or non-viral vectors) approaches. Nevertheless, considering the extraordinary complexity of processes involved in ageing and ageing-related diseases, the effectiveness of these therapeutic options is often unsatisfactory and limited by their side-effects. Thus, clinical implementation of such applications is certainly a long-time process that will require many translation phases for addressing challenges. However, after overcoming these issues, their implementation in clinical practice may obviously provide new possibilities in anti-ageing medicine. Here, we review and discuss recent advances in this rapidly developing research field.
2019
Vaiserman, A., De Falco, E., Koliada, A., Maslova, O., Balistreri, C.R. (2019). Anti-Ageing Gene Therapy: Not so Far Away?. AGEING RESEARCH REVIEWS, 56, 100977-100987 [10.1016/j.arr.2019.100977].
File in questo prodotto:
File Dimensione Formato  
ARR review _Vaiserman and Balistreri.pdf

Solo gestori archvio

Descrizione: pdf
Tipologia: Post-print
Dimensione 1.22 MB
Formato Adobe PDF
1.22 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/381122
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 13
social impact