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EnglishImproving healthspan is the main objective of anti-ageing research. Currently, innovative gene therapy-based approaches seem to be among the most promising for preventing and treating chronic polygenic pathologies, including age-related ones. The gene-based therapy allows to modulate the genome architecture using both direct (e.g., by gene editing) and indirect (e.g., by viral or non-viral vectors) approaches. Nevertheless, considering the extraordinary complexity of processes involved in ageing and ageing-related diseases, the effectiveness of these therapeutic options is often unsatisfactory and limited by their side-effects. Thus, clinical implementation of such applications is certainly a long-time process that will require many translation phases for addressing challenges. However, after overcoming these issues, their implementation in clinical practice may obviously provide new possibilities in anti-ageing medicine. Here, we review and discuss recent advances in this rapidly developing research field.
Vaiserman, A., De Falco, E., Koliada, A., Maslova, O., & Balistreri, C. (2019). Anti-Ageing Gene Therapy: Not so Far Away?. AGEING RESEARCH REVIEWS, 56, 100977-100987.
| Data di pubblicazione: | 2019 | |
| Titolo: | Anti-Ageing Gene Therapy: Not so Far Away? | |
| Autori: | BALISTRERI, Carmela Rita [Project Administration] | |
| Citazione: | Vaiserman, A., De Falco, E., Koliada, A., Maslova, O., & Balistreri, C. (2019). Anti-Ageing Gene Therapy: Not so Far Away?. AGEING RESEARCH REVIEWS, 56, 100977-100987. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.arr.2019.100977 | |
| Abstract: | Improving healthspan is the main objective of anti-ageing research. Currently, innovative gene therapy-based approaches seem to be among the most promising for preventing and treating chronic polygenic pathologies, including age-related ones. The gene-based therapy allows to modulate the genome architecture using both direct (e.g., by gene editing) and indirect (e.g., by viral or non-viral vectors) approaches. Nevertheless, considering the extraordinary complexity of processes involved in ageing and ageing-related diseases, the effectiveness of these therapeutic options is often unsatisfactory and limited by their side-effects. Thus, clinical implementation of such applications is certainly a long-time process that will require many translation phases for addressing challenges. However, after overcoming these issues, their implementation in clinical practice may obviously provide new possibilities in anti-ageing medicine. Here, we review and discuss recent advances in this rapidly developing research field. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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