The preparation and characterization of surface-PE Gylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG(2000) as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG(2000) copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.
CRAPARO EF, PITARRESI G, BONDI' ML, CASALETTO MP, LICCIARDI M, GIAMMONA G (2008). A NANOPARTICULATE DRUG-DELIVERY SYSTEM FOR RIVASTIGMINE: PHYSICO-CHEMICAL AND IN VITRO BIOLOGICAL CHARACTERIZATION. MACROMOLECULAR BIOSCIENCE, 8(3), 247-259.
A NANOPARTICULATE DRUG-DELIVERY SYSTEM FOR RIVASTIGMINE: PHYSICO-CHEMICAL AND IN VITRO BIOLOGICAL CHARACTERIZATION
CRAPARO, Emanuela Fabiola;PITARRESI, Giovanna;LICCIARDI, Mariano;GIAMMONA, Gaetano
2008-01-01
Abstract
The preparation and characterization of surface-PE Gylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG(2000) as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG(2000) copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.
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