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EnglishWe present preliminary data on the flow-induced haemodynamic and structural loads exerted on a penetrating atherosclerotic aortic ulcer (PAU). Specifically, one-way fluid-structure interaction analysis was performed on the aortic model reconstructed from a 66-year-old male patient with a PAU that evolved into an intramural haematoma and rupture of the thoracic aorta. The results show that elevated blood pressure (117 mmHg) and low flow velocity at the aortic wall (0.15 m/s(2)) occurred in the region of the PAU. We also found a low value of time-averaged wall shear stress (1.24 N/m(2)) and a high value of the temporal oscillation in the wall shear stress (oscillatory shear index = 0.13) in the region of the PAU. After endovascular treatment, these haemodynamic parameters were distributed uniformly on the luminal surface of the stent graft. These findings suggest that wall shear stress could be considered one of the major haemodynamic factors indicating the structural fragility of the PAU wall, which ultimately lead to PAU growth and rupture.
| Data di pubblicazione: | 2013 |
| Titolo: | Haemodynamic predictors of a penetrating atherosclerotic ulcer rupture using fluid-structure interaction analysis |
| Autori: | |
| Citazione: | D'Ancona, G., Amaducci, A., Rinaudo, A., Pasta, S., Follis, F., Pilato, M., et al. (2013). Haemodynamic predictors of a penetrating atherosclerotic ulcer rupture using fluid-structure interaction analysis. INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 17(3), 576-578. |
| Rivista: | |
| Digital Object Identifier (DOI): | 10.1093/icvts/ivt245 |
| Abstract: | We present preliminary data on the flow-induced haemodynamic and structural loads exerted on a penetrating atherosclerotic aortic ulcer (PAU). Specifically, one-way fluid-structure interaction analysis was performed on the aortic model reconstructed from a 66-year-old male patient with a PAU that evolved into an intramural haematoma and rupture of the thoracic aorta. The results show that elevated blood pressure (117 mmHg) and low flow velocity at the aortic wall (0.15 m/s(2)) occurred in the region of the PAU. We also found a low value of time-averaged wall shear stress (1.24 N/m(2)) and a high value of the temporal oscillation in the wall shear stress (oscillatory shear index = 0.13) in the region of the PAU. After endovascular treatment, these haemodynamic parameters were distributed uniformly on the luminal surface of the stent graft. These findings suggest that wall shear stress could be considered one of the major haemodynamic factors indicating the structural fragility of the PAU wall, which ultimately lead to PAU growth and rupture. |
| Settore Scientifico Disciplinare: | Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di Macchine Settore ING-IND/34 - Bioingegneria Industriale |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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