An intrinsic feature of behaviour orbits around its temporal dimension consisting of patterns in time: investigations on behaviour necessarily deal with sequences often impossible to be perceived by the human eye [Eibl-Eibesfeldt I. Ethology: the biology of behavior. New York: Holt, Rinehart and Winston. 1970]. Thus, the study of behavioural sequencing in terms of higher order arrangements, how the sequences are structured and, importantly, their analysis in normal subjects and in subjects affected by specific movement/behavioural disorders may represent a stimulating but challenging task. By means of T-Pattern analysis (TPA), it is possible to study these hidden features of behaviour and, specifically, its sequential organization [Casarrubea M et al. J Neurosci Methods. 2015;239:34-46]. This is particularly interesting when such a multivariate technique is used to study animal models of neurological illnesses characterized by movement disorders such as Parkinson’s disease, Tourette’s syndrome or histamine-depleted conditions. Here we illustrate our recent findings, obtained by means of TPA, in different rodent models presenting movement disorders [Casarrubea M et al. Behav Brain Res 2019;362:28-35; Santangelo A et al. CNS Neurosci Ther 2018;24:703-711; Santangelo A et al. Neuropharmacology. 2017;113:533-542]. The results may represent a stimulating topic of discussion on what, from a translational perspective, each model may suggest in terms of human behavioural abnormalities. We propose TPA as a suitable tool to describe the architecture of a behaviour both in animal models of neurological disorders and human patients as well

Casarrubea M, A.S. (2019). T-Patterns in the study of movement disorders. ACTA PHYSIOLOGICA, 227(S718), 73-73.

T-Patterns in the study of movement disorders

Casarrubea M
Writing – Review & Editing
;
Aiello S.
Writing – Review & Editing
;
Crescimanno G
Supervision
2019-01-01

Abstract

An intrinsic feature of behaviour orbits around its temporal dimension consisting of patterns in time: investigations on behaviour necessarily deal with sequences often impossible to be perceived by the human eye [Eibl-Eibesfeldt I. Ethology: the biology of behavior. New York: Holt, Rinehart and Winston. 1970]. Thus, the study of behavioural sequencing in terms of higher order arrangements, how the sequences are structured and, importantly, their analysis in normal subjects and in subjects affected by specific movement/behavioural disorders may represent a stimulating but challenging task. By means of T-Pattern analysis (TPA), it is possible to study these hidden features of behaviour and, specifically, its sequential organization [Casarrubea M et al. J Neurosci Methods. 2015;239:34-46]. This is particularly interesting when such a multivariate technique is used to study animal models of neurological illnesses characterized by movement disorders such as Parkinson’s disease, Tourette’s syndrome or histamine-depleted conditions. Here we illustrate our recent findings, obtained by means of TPA, in different rodent models presenting movement disorders [Casarrubea M et al. Behav Brain Res 2019;362:28-35; Santangelo A et al. CNS Neurosci Ther 2018;24:703-711; Santangelo A et al. Neuropharmacology. 2017;113:533-542]. The results may represent a stimulating topic of discussion on what, from a translational perspective, each model may suggest in terms of human behavioural abnormalities. We propose TPA as a suitable tool to describe the architecture of a behaviour both in animal models of neurological disorders and human patients as well
2019
Joint Meeting of the Federation of European Physiological Societies (FEPS) and the Italian Physiological Society (SIF)
Bologna (Italy)
September 10th – 13th 2019
Casarrubea M, A.S. (2019). T-Patterns in the study of movement disorders. ACTA PHYSIOLOGICA, 227(S718), 73-73.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/372810
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