Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.
EnglishAcetaldehyde contributes to alcohol’s neuroactive effects through its own motivational properties. This chapter gathers current evidence on acetaldehyde psychoactive action, focusing on behavioral investigations able to unveil acetaldehyde rewarding effects and their pharmacological modulation in vivo. Acetaldehyde induces conditioned place preference for paired environment and cues and is dose-dependently self-administered in a two-bottle choice drinking paradigm. Acetaldehyde’s motivational properties are further highlighted by operant paradigms tailored to model several addiction-like behaviors, such as induction and maintenance of operant responding, drug-seeking in extinction, relapse following deprivation, and resistance to punishment. Acetaldehyde-related behaviors are sensitive to pharmacological manipulations of dopamine and endocannabinoid signaling, two systems that functionally interplay in controlling motivation. This evidence holds promising potential for the development of novel pharmacological approaches aimed at reducing alcohol abuse.
| Data di pubblicazione: | 2019 |
| Titolo: | Acetaldehyde and Motivation |
| Autori: | |
| Citazione: | Brancato, A., & Cannizzaro, C. (2019). Acetaldehyde and Motivation. In Preedy VR (a cura di), Neuroscience of Alcohol (pp. 345-353). |
| Abstract: | Acetaldehyde contributes to alcohol’s neuroactive effects through its own motivational properties. This chapter gathers current evidence on acetaldehyde psychoactive action, focusing on behavioral investigations able to unveil acetaldehyde rewarding effects and their pharmacological modulation in vivo. Acetaldehyde induces conditioned place preference for paired environment and cues and is dose-dependently self-administered in a two-bottle choice drinking paradigm. Acetaldehyde’s motivational properties are further highlighted by operant paradigms tailored to model several addiction-like behaviors, such as induction and maintenance of operant responding, drug-seeking in extinction, relapse following deprivation, and resistance to punishment. Acetaldehyde-related behaviors are sensitive to pharmacological manipulations of dopamine and endocannabinoid signaling, two systems that functionally interplay in controlling motivation. This evidence holds promising potential for the development of novel pharmacological approaches aimed at reducing alcohol abuse. |
| Digital Object Identifier (DOI): | 10.1016/B978-0-12-813125-1.00036-2 |
| Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia |
| Appare nelle tipologie: | 2.01 Capitolo o Saggio |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Brancato and Cannizzaro in Preedy-1631508.pdf | Versione Editoriale | Administrator Richiedi una copia |
Copyright © 2020