Gender-Related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe. A Report From the Euro Heart Survey on Atrial Fibrillation

Dagres, N.; Nieuwlaat, R.; Vardas, P.; Andresen, D.; Levy, S.; Cobbe, S.; Kremastinos, D.; Breithardt, G.; Cokkinos, D.; Crijns, H.; Camm, A.; Davies, W.; Capucci, A.; Olsson, B.; Aliot, E.; Le Heuzey, J.; Santini, M.; Manini, M.; Bramley, C.; Laforest, V.; Taylor, C.; Del Gaiso, S.; Huber, K.; De Backer, G.; Sirakova, V.; Cerbak, R.; Thayssen, P.; Lehto, S.; Blanc, J.; Delahaye, F.; Kobulia, B.; Zeymer, U.; Karlocai, K.; Graham, I.; Shelley, E.; Behar, S.; Maggioni, A.; Goncalves, L.; Grabauskiene, V.; Asmussen, I.; Deckers, J.; Stepinska, J.; Mareev, V.; Vasiljevic, Z.; Riecansky, I.; Kenda, M.; Alonso, A.; Lopez-Sendon, J.; Rosengren, A.; Buser, P.; Okay, T.; Sychov, O.; Fox, K.; Schofield, P.; Simoons, M.; Wood, D.; Battler, A.; Boersma, E.; Fox, K.; Komajda, M.; Mcgregor, K.; Mulder, B.; Priori, S.; Ryden, L.; Vahanian, A.; Wijns, W.; Sanofi-Aventis,; Grigoryan, S.; Apetyan, I.; Aroyan, S.; Azarapetyan, L.; Anvari, A.; Gottsauner-Wolf, M.; Pfaffenberger, S.; Aydinkoc, K.; Kalla, K.; Penka, M.; Drexel, H.; Langer, P.; Pierard, L.; Legrand, V.; Blommaert, D.; Schroeder, E.; Mancini, I.; Geelen, P.; Brugada, P.; De Zutter, M.; Vrints, C.; Vercammen, M.; Morissens, M.; Borisov, B.; Petrov, V.; Marinova, M.; Assen, A.; Goudev, R.; Peychev, Y.; Stoyanovsky, V.; Stoynev, E.; Kranjcevic, S.; Moutiris, J.; Ioannides, M.; Evequoz, D.; Spacilova, J.; Novak, M.; Eisenberger, M.; Mullerova, J.; Kautzner, J.; Riedlbauchova, L.; Petru`, J.; Taborsky, M.; Cappelen, H.; Sharaf, Y.; Ibrahim, B.; Tammam, K.; Saad, A.; Elghawaby, H.; Sherif, H.; Farouk, H.; Mielke, A.; Engelen, M.; Kirchhof, P.; Zimmermann, P.; Aviles, F.; Rubio, J.; Malpartida, F.; Corona, M.; Sanchez, L.; Miguel, J.; Herrera, L.; Quesada, A.; Garcia, A.; Gonzalez, C.; Juango, M.; Berjon-Reyero, J.; Alegret, J.; Fernandez, J.; Carrascosa, C.; Romero, R.; Lara, M.; Sendon, J.; de Diego, J.; Martin, L.; Irurita, M.; Guttierez, N.; Rubio, J.; Antorrena, I.; Paves, A.; Salvador, A.; Orriach, M.; Garcia, A.; Epelde, F.; Martinez, V.; Sanchez, A.; Galvez, C.; Rivero, R.; Madrid, A.; Baron-Esquivias, G.; Peinado, R.; Guindal, J.; Vera, T.; Fernandez, E.; Gayan, R.; Garcia, J.; Bodegas, A.; Lopez, J.; Florez, J.; Cabezas, C.; de Castroviejo, E.; Bellido, J.; Ruiz, M.; Savolainen, K.; Nieminen, M.; Toivonen, L.; Syvanne, M.; Pietila, M.; Galley, D.; Beltra, C.; Gay, A.; Daubert, J.; Lecocq, G.; Poulain, C.; Cleland, J.; Shelton, R.; Choudhury, A.; Abuladze, G.; Jashi, I.; Tsiavou, A.; Giamouzis, G.; Kostopoulou, A.; Tsoutsanis, D.; Stefanadis, C.; Latsios, G.; Vogiatzis, I.; Gotsis, A.; Bozia, P.; Karakiriou, M.; Koulouris, S.; Parissis, J.; Kostakis, G.; Kouris, N.; Kontogianni, D.; Athanasios, K.; Douras, A.; Tsanakis, T.; Marketou, M.; Patsourakos, N.; Czopf, L.; Halmosi, R.; Preda, I.; Csoti, E.; Badics, A.; Strasberg, B.; Freedberg, N.; Katz, A.; Zalzstein, E.; Grosbard, A.; Goldhammer, E.; Nahir, M.; Epstein, M.; Vider, I.; Luria, D.; Mandelzweig, L.; Aloisi, B.; Cavallaro, A.; Antonielli, E.; Doronzo, B.; Pancaldo, D.; Mazzola, C.; Buontempi, L.; Calvi, V.; Giuffrida, G.; Figlia, A.; Ippolito, F.; Gelmini, G.; Gaibazzi, N.; Ziacchi, V.; De Tommasi, F.; Lombardi, F.; Fiorentini, C.; Terranova, P.; Maiolino, P.; Albunni, M.; Pinna-Pintor, P.; Fumagalli, S.; Masotti, G.; Boncinelli, L.; Rossi, D.; Santoro, G.; Fioranelli, M.; Naccarella, F.; Maranga, S.; Lepera, G.; Bresciani, B.; Seragnoli, E.; Forti, M.; Cortina, V.; Baciarello, G.; Cicconetti, P.; Lax, A.; Vitali, F.; Igidbashian, D.; Scarpino, L.; Terrazzino, S.; Tavazzi, L.; Cantu, F.; Pentimalli, F.; Novo, S.; Coppola, G.; Zingarini, G.; Ambrozio, G.; Moruzzi, P.; Callegari, S.; Saccomanno, G.; Russo, P.; Carbonieri, E.; Paino, A.; Zanetta, M.; Barducci, E.; Cemin, R.; Rauhe, W.; Pitscheider, W.; Meloni, M.; Marchi, S.; Di Gennaro, M.; Calcagno, S.; Squaratti, P.; Quartili, F.; Bertocchi, P.; De Martini, M.; Mantovani, G.; Komorovsky, R.; Desideri, A.; Celegon, L.; Tarantini, L.; Catania, G.; Lucci, D.; Bianchini, F.; Puodziukynas, A.; Kavoliuniene, A.; Barauskiene, V.; Aidietis, A.; Barysiene, J.; Vysniauskas, V.; Zukauskiene, I.; Kazakeviciene, N.; Georgievska-Ismail, L.; Poposka, L.; Vataman, E.; Grosu, A.; op Reimer, W.; de Swart, E.; Lenzen, M.; Jansen, C.; Brons, R.; Tebbe, H.; van Hoogenhuyze, D.; Veerhoek, M.; Kamps, M.; Haan, D.; van Rijn, N.; Bootsma, A.; Baur, L.; van den, A.; Fransen, H.; Eurlings, L.; Meeder, J.; De Boer, M.; Winter, J.; Broers, H.; Werter, C.; Bijl, M.; Versluis, S.; Milkowska, M.; Wozakowska-Kaplon, B.; Janion, M.; Lepska, L.; Swiatecka, G.; Kokowicz, P.; Cybulski, J.; Gorecki, A.; Szulc, M.; Rekosz, J.; Manczak, R.; Wnuk-Wojnar, A.; Trusz-Gluza, M.; Rybicka-Musialik, A.; Myszor, J.; Szpajer, M.; Cymerman, K.; Sadowski, J.; Sniezek-Maciejewska, M.; Ciesla-Dul, M.; Gorkiewicz-Kot, I.; Grodzicki, T.; Rewiuk, K.; Kubik, L.; Lewit, J.; de Sousa, J.; Ferreira, R.; Freitas, A.; Morais, J.; Pires, R.; Gomes, M.; Gago, P.; Candeias, R.; Nunes, L.; J. V. M., S.; Ventura, M.; de Oliveira, M.; Alves, L.; Bostaca, I.; Olariu, C.; Dan, G.; Dan, A.; Podoleanu, C.; Frigy, A.; Georgescu, G.; Arsenescu, C.; Statescu, C.; Sascau, R.; Dimitrascu, D.; Rancea, R.; Shubik, Y.; Duplyakov, D.; Shalak, M.; Danielyan, M.; Galyavich, A.; Zakirova, V.; Hatala, R.; Kaliska, G.; Kmec, J.; Zupan, I.; Tasie`, J.; Vokac, D.; Edvardsson, N.; Poci, D.; Gamra, H.; Denguir, H.; Sepetoglu, A.; Arat-Ozkan, A.; Orynchak, M.; Paliy, E.; Vakalyuk, I.; Malidze, D.; Prog, R.; Yabluchansky, M.; Makienko, N.; Potpara, T.; Knezevic, S.; Randjelovic, M.

doi:10.1016/j.jacc.2006.10.047

Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.

Objectives: This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe. Background: Gender-related differences may play a significant role in AF. Methods: We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation. Results: Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019). Conclusions: Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar. © 2007 American College of Cardiology Foundation.

Data di pubblicazione:	2007
Titolo:	Gender-Related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe. A Report From the Euro Heart Survey on Atrial Fibrillation
Autori:	Dagres N. Nieuwlaat R. Vardas P. E. Andresen D. Levy S. Cobbe S. Kremastinos D. Th. Breithardt G. Cokkinos D. V. Crijns H. J. G. M. Camm A. J. Davies W. Capucci A. Olsson B. Aliot E. Le Heuzey J. -Y. Santini M. Manini M. Bramley C. Laforest V. Taylor C. Del Gaiso S. Huber K. De Backer G. Sirakova V. Cerbak R. Thayssen P. Lehto S. Blanc J. -J. Delahaye F. Kobulia B. Zeymer U. Karlocai K. Graham I. Shelley E. Behar S. Maggioni A. Goncalves L. Grabauskiene V. Asmussen I. Deckers J. Stepinska J. Mareev V. Vasiljevic Z. Riecansky I. Kenda M. F. Alonso A. Lopez-Sendon J. L. Rosengren A. Buser P. Okay T. Sychov O. Fox K. Schofield P. Simoons M. Wood D. Battler A. Boersma E. Fox K. Komajda M. McGregor K. Mulder B. Priori S. Ryden L. Vahanian A. Wijns W. Sanofi-Aventis Grigoryan S. V. Apetyan I. Aroyan S. Azarapetyan L. Anvari A. Gottsauner-Wolf M. Pfaffenberger S. Aydinkoc K. Kalla K. Penka M. Drexel H. Langer P. Pierard L. A. Legrand V. Blommaert D. Schroeder E. Mancini I. Geelen P. Brugada P. De Zutter M. Vrints C. Vercammen M. Morissens M. Borisov B. Petrov V. A. Marinova M. Assen A. Goudev R. Peychev Y. Stoyanovsky V. Stoynev E. Kranjcevic S. Moutiris J. Ioannides M. Evequoz D. Spacilova J. Novak M. Eisenberger M. Mullerova J. Kautzner J. Riedlbauchova L. Petru` J. Taborsky M. Cappelen H. Sharaf Y. A. Ibrahim B. S. S. Tammam K. Saad A. Elghawaby H. Sherif H. Z. Farouk H. Mielke A. Engelen M. Kirchhof P. Zimmermann P. Aviles F. F. Santolaya Rubio, Javier Malpartida F. Corona M. Sanchez L. T. Miguel J. Herrera L. Quesada A. Garcia A. J. M. Gonzalez C. S. Juango M. S. A. Berjon-Reyero J. Alegret J. M. Fernandez J. M. C. Carrascosa C. Romero R. A. F. Lara M. G. Sendon J. L. L. de Diego J. J. G. Martin L. S. Irurita M. Guttierez N. H. Rubio J. R. S. Antorrena I. Paves A. B. Salvador A. Orriach M. D. Garcia A. A. Epelde F. MARTINEZ, VITO BRUNO Sanchez A. B. Galvez C. P. Rivero R. F. Madrid A. H. Baron-Esquivias G. Peinado R. Guindal J. A. G. Vera T. R. Fernandez E. L. Gayan R. Brandariz Garcia, Josè Angel Bodegas A. Lopez J. T. Florez J. M. Cabezas C. L. de Castroviejo E. V. R. Bellido J. M. Ruiz M. E. Savolainen K. Nieminen M. Toivonen L. Syvanne M. Pietila M. Galley D. Beltra C. Gay A. Daubert J. C. Lecocq G. Poulain C. Cleland J. G. F. C. Shelton R. Choudhury A. Abuladze G. Jashi I. Tsiavou A. Giamouzis G. Kostopoulou A. Tsoutsanis D. Stefanadis C. Latsios G. Vogiatzis I. Gotsis A. Bozia P. Karakiriou M. Koulouris S. Parissis J. Kostakis G. Kouris N. Kontogianni D. Athanasios K. Douras A. Tsanakis T. Marketou M. Patsourakos N. Czopf L. Halmosi R. Preda I. Csoti E. Badics A. Strasberg B. Freedberg N. A. Katz A. Zalzstein E. Grosbard A. Goldhammer E. Nahir M. Epstein M. Vider I. Luria D. Mandelzweig L. Aloisi B. Cavallaro A. Antonielli E. Doronzo B. Pancaldo D. Mazzola C. Buontempi L. Calvi V. Giuffrida G. Figlia A. Ippolito F. Gelmini G. -P. Gaibazzi N. Ziacchi V. De Tommasi F. LOMBARDI, Franco Fiorentini C. Terranova P. Maiolino P. Albunni M. Pinna-Pintor P. Fumagalli S. Masotti G. Boncinelli L. ROSSI, David Santoro G. M. Fioranelli M. Naccarella F. Maranga S. S. Lepera G. Bresciani B. Seragnoli E. Forti M. C. Cortina V. Baciarello G. Cicconetti P. Lax A. Vitali F. Igidbashian D. Scarpino L. Terrazzino S. Tavazzi L. Cantu F. Pentimalli F. NOVO, Salvatore COPPOLA, Giuseppe Zingarini G. Ambrozio G. Moruzzi P. Callegari S. Saccomanno G. Russo P. Carbonieri E. Paino A. Zanetta M. Barducci E. Cemin R. Rauhe W. Pitscheider W. MELONI, Maurizio Marchi S. M. Di Gennaro M. Calcagno S. Squaratti P. Quartili F. Bertocchi P. De Martini M. MANTOVANI, Dario Giuseppe Komorovsky R. DESIDERI, ALESSANDRO Celegon L. Tarantini L. Catania G. Lucci D. Bianchini F. Puodziukynas A. Kavoliuniene A. Barauskiene V. Aidietis A. Barysiene J. Vysniauskas V. Zukauskiene I. Kazakeviciene N. Georgievska-Ismail L. Poposka L. Vataman E. Grosu A. A. op Reimer W. S. de Swart E. Lenzen M. Jansen C. Brons R. Tebbe H. van Hoogenhuyze D. C. A. Veerhoek M. J. Kamps M. Haan D. van Rijn N. Bootsma A. Baur L. van den A. Fransen H. Eurlings L. Meeder J. De Boer M. J. Winter J. Broers H. Werter C. Bijl M. Versluis S. Milkowska M. Wozakowska-Kaplon B. Janion M. Lepska L. Swiatecka G. Kokowicz P. Cybulski J. Gorecki A. Szulc M. Rekosz J. Manczak R. Wnuk-Wojnar A. -M. Trusz-Gluza M. Rybicka-Musialik A. Myszor J. Szpajer M. Cymerman K. Sadowski J. Sniezek-Maciejewska M. Ciesla-Dul M. Gorkiewicz-Kot I. Grodzicki T. Rewiuk K. Kubik L. Lewit J. de Sousa J. M. F. R. Ferreira R. Freitas A. Morais J. C. A. Pires R. Gomes M. J. V. Gago P. Candeias R. A. C. Nunes L. Sa J. V. M. Ventura M. de Oliveira M. Alves L. B. Bostaca I. Olariu C. T. Dan G. A. Dan A. Podoleanu C. Frigy A. Georgescu G. I. M. Arsenescu C. Statescu C. Sascau R. Dimitrascu D. L. Rancea R. Shubik Y. V. Duplyakov D. Shalak M. Danielyan M. Galyavich A. Zakirova V. Hatala R. Kaliska G. Kmec J. Zupan I. Tasie` J. Vokac D. Edvardsson N. Poci D. Gamra H. Denguir H. Sepetoglu A. Arat-Ozkan A. Orynchak M. Paliy E. Vakalyuk I. Malidze D. Prog R. Yabluchansky M. I. Makienko N. V. Potpara T. Knezevic S. Randjelovic M. mostra contributor esterni nascondi contributor esterni
Citazione:	Dagres, N., Nieuwlaat, R., Vardas, P., Andresen, D., Levy, S., Cobbe, S., et al. (2007). Gender-Related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe. A Report From the Euro Heart Survey on Atrial Fibrillation. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(5), 572-577.
Rivista:	JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Digital Object Identifier (DOI):	10.1016/j.jacc.2006.10.047
Abstract:	Objectives: This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe. Background: Gender-related differences may play a significant role in AF. Methods: We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation. Results: Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019). Conclusions: Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar. © 2007 American College of Cardiology Foundation.
URL:	www.elsevier.com/locate/jacc
Appare nelle tipologie:	1.01 Articolo in rivista

File in questo prodotto:

Non ci sono file associati a questo prodotto.

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/10447/365118

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.