Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation.
Spatari, G., Fenga, C., Minciullo, P., Di Pasquale, G., Cacciola, A., Ventura-Spagnolo, E., et al. (2005). Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents. MEDIATORS OF INFLAMMATION, 2005(1), 60-62 [10.1155/MI.2005.60].
Data di pubblicazione: | 2005 | |
Titolo: | Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents | |
Autori: | ||
Citazione: | Spatari, G., Fenga, C., Minciullo, P., Di Pasquale, G., Cacciola, A., Ventura-Spagnolo, E., et al. (2005). Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents. MEDIATORS OF INFLAMMATION, 2005(1), 60-62 [10.1155/MI.2005.60]. | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1155/MI.2005.60 | |
Abstract: | Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation. | |
Settore Scientifico Disciplinare: | Settore MED/43 - Medicina Legale | |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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