Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
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EnglishCytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation.
| Data di pubblicazione: | 2005 |
| Titolo: | Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents |
| Autori: | |
| Citazione: | Spatari, G., Fenga, C., Minciullo, P., Di Pasquale, G., Cacciola, A., Ventura-Spagnolo, E., et al. (2005). Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents. MEDIATORS OF INFLAMMATION, 2005(1), 60-62. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1155/MI.2005.60 |
| Abstract: | Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation. |
| Settore Scientifico Disciplinare: | Settore MED/43 - Medicina Legale |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Modification of interleukin 15_2005.pdf | articolo principale | Post-print | Open Access Visualizza/Apri |
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