Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.
EnglishCytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation.
Spatari, G., Fenga, C., Minciullo, P., Di Pasquale, G., Cacciola, A., Ventura-Spagnolo, E., et al. (2005). Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents. MEDIATORS OF INFLAMMATION, 2005(1), 60-62.
| Data di pubblicazione: | 2005 |
| Titolo: | Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents |
| Autori: | |
| Citazione: | Spatari, G., Fenga, C., Minciullo, P., Di Pasquale, G., Cacciola, A., Ventura-Spagnolo, E., et al. (2005). Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents. MEDIATORS OF INFLAMMATION, 2005(1), 60-62. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1155/MI.2005.60 |
| Abstract: | Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation. |
| Settore Scientifico Disciplinare: | Settore MED/43 - Medicina Legale |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Modification of interleukin 15_2005.pdf | articolo principale | Post-print | Open Access Visualizza/Apri |
Copyright © 2021