Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.
EnglishMetastatic melanoma is still associated with a poor prognosis, and there is increasing interest in immunotherapy alone or in combination with other adjuvant therapies. Γδ T lymphocytes play a pivot role in the immune response against cancer, but while γδ-based immunotherapy is already a clinical reality for several solid tumors, data on melanoma are still limited and fragmented. This systematic review presents preclinical and clinical evidence for a role of γδ T lymphocytes in immunotherapeutic strategies for advanced melanoma and discusses research state of the art and future perspectives. Current strategies focus on in vivo stimulation, and ex vivo adoptive therapy and vaccination; results are promising, but further studies are needed to better investigate the interactions in tumoral microenvironment and to improve clinical efficacy of immunotherapeutic protocols.
Toia, F., Di Stefano, A., Meraviglia, S., Lo Presti, E., Pirrello, R., Rinaldi, G., et al. (2019). Γ δ T Cell-Based Immunotherapy in Melanoma: State of the Art. JOURNAL OF ONCOLOGY, 2019.
| Data di pubblicazione: | 2019 |
| Titolo: | Γ δ T Cell-Based Immunotherapy in Melanoma: State of the Art |
| Autori: | |
| Citazione: | Toia, F., Di Stefano, A., Meraviglia, S., Lo Presti, E., Pirrello, R., Rinaldi, G., et al. (2019). Γ δ T Cell-Based Immunotherapy in Melanoma: State of the Art. JOURNAL OF ONCOLOGY, 2019. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1155/2019/9014607 |
| Abstract: | Metastatic melanoma is still associated with a poor prognosis, and there is increasing interest in immunotherapy alone or in combination with other adjuvant therapies. Γδ T lymphocytes play a pivot role in the immune response against cancer, but while γδ-based immunotherapy is already a clinical reality for several solid tumors, data on melanoma are still limited and fragmented. This systematic review presents preclinical and clinical evidence for a role of γδ T lymphocytes in immunotherapeutic strategies for advanced melanoma and discusses research state of the art and future perspectives. Current strategies focus on in vivo stimulation, and ex vivo adoptive therapy and vaccination; results are promising, but further studies are needed to better investigate the interactions in tumoral microenvironment and to improve clinical efficacy of immunotherapeutic protocols. |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Toia F.pdf | Versione Editoriale | Open Access Visualizza/Apri |
Copyright © 2021