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EnglishCardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women.
Madonna, R., Balistreri, C.R., De Rosa, S., Muscoli, S., Selvaggio, S., Selvaggio, G., et al. (2019). Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease.
| Data di pubblicazione: | 2019 |
| Titolo: | Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease |
| Autori: | |
| Citazione: | Madonna, R., Balistreri, C.R., De Rosa, S., Muscoli, S., Selvaggio, S., Selvaggio, G., et al. (2019). Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/jcm8010098 |
| Abstract: | Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women. |
| Settore Scientifico Disciplinare: | Settore MED/05 - Patologia Clinica |
| Appare nelle tipologie: | 1.09 Review essay (rassegna critica) |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| jcm-08-00098 Madonna published.1.pdf | pdf paper pubblicato | Post-print | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/361587
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