Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease

Madonna, R.; Balistreri, C.; De Rosa, S.; Muscoli, S.; Selvaggio, S.; Selvaggio, G.; Ferdinandy, P.; De Caterina, R.

doi:10.3390/jcm8010098

Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.

Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women.

Data di pubblicazione:	2019
Titolo:	Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease
Autori:	Madonna, Rosalinda (Corresponding) BALISTRERI, Carmela Rita [Writing – Review & Editing] De Rosa, Salvatore Muscoli, Saverio Selvaggio, Stefano Selvaggio, Giancarlo Ferdinandy, Péter De Caterina, Raffaele mostra contributor esterni nascondi contributor esterni
Citazione:	Madonna, R., Balistreri, C., De Rosa, S., Muscoli, S., Selvaggio, S., Selvaggio, G., et al. (2019). Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease. JOURNAL OF CLINICAL MEDICINE, 8(1), 98.
Rivista:	JOURNAL OF CLINICAL MEDICINE
Digital Object Identifier (DOI):	10.3390/jcm8010098
Abstract:	Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women.
URL:	https://www.mdpi.com/journal/jcm
Settore Scientifico Disciplinare:	Settore MED/05 - Patologia Clinica
Appare nelle tipologie:	1.01 Articolo in rivista

File in questo prodotto:

File	Descrizione	Tipologia	Licenza
jcm-08-00098 Madonna published.1.pdf	pdf paper pubblicato	Post-print		Open Access Visualizza/Apri

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/10447/361587

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.