Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease

Madonna, R; Balistreri, CR; De Rosa, S; Muscoli, S; Selvaggio, S; Selvaggio, G; Ferdinandy, P; De Caterina, R

doi:10.3390/jcm8010098

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Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women.

Data di pubblicazione:	2019
Titolo:	Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease
Autori:	Madonna, Rosalinda (Corresponding) BALISTRERI, Carmela Rita [Writing – Review & Editing] De Rosa, Salvatore Muscoli, Saverio Selvaggio, Stefano Selvaggio, Giancarlo Ferdinandy, Péter De Caterina, Raffaele mostra contributor esterni nascondi contributor esterni
Citazione:	Madonna, R., Balistreri, C., De Rosa, S., Muscoli, S., Selvaggio, S., Selvaggio, G., et al. (2019). Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease. JOURNAL OF CLINICAL MEDICINE, 8(1), 98.
Rivista:	JOURNAL OF CLINICAL MEDICINE
Digital Object Identifier (DOI):	http://dx.doi.org/10.3390/jcm8010098
Abstract:	Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women.
URL:	https://www.mdpi.com/journal/jcm
Settore Scientifico Disciplinare:	Settore MED/05 - Patologia Clinica
Appare nelle tipologie:	1.01 Articolo in rivista

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