Nanogels are very promising biomedical nanodevices. The classic “radiation chemistry-based” approach to synthetize nanogels consists in the irradiation with pulsed electron beams of dilute, N 2 O-saturated, aqueous solutions of water-soluble polymers of the “crosslinking type”. Nanogels with controlled size and properties are produced in a single irradiation step with no recourse to initiators, organic solvents and surfactants. This paper combines experimental syntheses, performed with two e-beam irradiation setups and dose-ranges, starting from poly(N-vinyl pyrrolidone) solutions of various concentrations, both in N 2 O-saturated and air-saturated initial conditions, with the numerical simulations of the radiation chemistry of aqueous solutions of a radical scavanger exposed to the same irradiation conditions used in the experiments. This approach provides a methodology to predict the impact of system and irradiation conditions on the water radiation chemistry, which in turn affect the nanogel features in terms of molecular and physico-chemical properties. In particular, the crucial role of initial and transient concentration of molecular oxygen is revealed. This work also proposes a very simple and effective methodology to quantitatively measure the double bonds formed in the systems from disporportionation and chain scission reactions, competing with inter-/intra-molecular crosslinking.

Ditta L.A., Dahlgren B., Sabatino M.A., Dispenza C., Jonsson M. (2019). The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels. EUROPEAN POLYMER JOURNAL, 114, 164-175 [10.1016/j.eurpolymj.2019.02.020].

The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels

Ditta L. A.;Sabatino M. A.;Dispenza C.;Jonsson M.
2019-01-01

Abstract

Nanogels are very promising biomedical nanodevices. The classic “radiation chemistry-based” approach to synthetize nanogels consists in the irradiation with pulsed electron beams of dilute, N 2 O-saturated, aqueous solutions of water-soluble polymers of the “crosslinking type”. Nanogels with controlled size and properties are produced in a single irradiation step with no recourse to initiators, organic solvents and surfactants. This paper combines experimental syntheses, performed with two e-beam irradiation setups and dose-ranges, starting from poly(N-vinyl pyrrolidone) solutions of various concentrations, both in N 2 O-saturated and air-saturated initial conditions, with the numerical simulations of the radiation chemistry of aqueous solutions of a radical scavanger exposed to the same irradiation conditions used in the experiments. This approach provides a methodology to predict the impact of system and irradiation conditions on the water radiation chemistry, which in turn affect the nanogel features in terms of molecular and physico-chemical properties. In particular, the crucial role of initial and transient concentration of molecular oxygen is revealed. This work also proposes a very simple and effective methodology to quantitatively measure the double bonds formed in the systems from disporportionation and chain scission reactions, competing with inter-/intra-molecular crosslinking.
2019
Ditta L.A., Dahlgren B., Sabatino M.A., Dispenza C., Jonsson M. (2019). The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels. EUROPEAN POLYMER JOURNAL, 114, 164-175 [10.1016/j.eurpolymj.2019.02.020].
File in questo prodotto:
File Dimensione Formato  
European Polymer Ditta 2019.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 1.35 MB
Formato Adobe PDF
1.35 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/359657
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 14
social impact