The complexation of one steroid antibiotic of the fusidane family, sodium fusidate [sodium 2-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12, 13,15,16-dodeca hydro-1H-cyclopenta[a]phenanthren-7-ylidene)-6-methyl-hept-5-enoate = (Nafus)], by dialkyltin(IV) has been studied by conventional technique as FT-IR, Mössbauer and NMR spectroscopies. Analytical data supported the general formula Alk2Sn(IV)fus2 (Alk = Me, Bu). Infrared spectral data of the complexes imply the presence of both uni- and bidentate, ester-type and bridging carboxylate group, respectively. On the basis of FT-IR and 119Sn Mössbauer spectroscopy, in both Me2Sn(IV)fus2 and Bu2Sn(IV)fus2, trigonal bipyramidal configurations are proposed. NMR spectra, of both ligand and of the complexes were carried in DMSO-d6 solution, in which dialkyltin(IV)bis(fusidate) maintained their solid-state configuration. In vitro antimicrobial tests were performed on complexes, and good anti-staphylococcal activity was observed.
FIORE T, ABBATE M, CASELLA G, CATALDO S, NAGY L, PELLERITO C, et al. (2008). Synthesis, Characterization and in vitro antimicrobial activity of dialkyltin(IV)bis(fusidate) complexes. ATTI DELLA ACCADEMIA DI SCIENZE, LETTERE E ARTI DI PALERMO, PARTE PRIMA: SCIENZE, SERIE QUINTA, VOL. XXIV (TOMO I: Scienze), 75-88.
Synthesis, Characterization and in vitro antimicrobial activity of dialkyltin(IV)bis(fusidate) complexes.
FIORE, Tiziana;ABBATE, Michele;CASELLA, Girolamo;CATALDO, Salvatore;PELLERITO, Claudia;PRINZIVALLI, Cristina;SCHILLACI, Domenico;SCOPELLITI, Michelangelo;PELLERITO, Lorenzo
2008-01-01
Abstract
The complexation of one steroid antibiotic of the fusidane family, sodium fusidate [sodium 2-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12, 13,15,16-dodeca hydro-1H-cyclopenta[a]phenanthren-7-ylidene)-6-methyl-hept-5-enoate = (Nafus)], by dialkyltin(IV) has been studied by conventional technique as FT-IR, Mössbauer and NMR spectroscopies. Analytical data supported the general formula Alk2Sn(IV)fus2 (Alk = Me, Bu). Infrared spectral data of the complexes imply the presence of both uni- and bidentate, ester-type and bridging carboxylate group, respectively. On the basis of FT-IR and 119Sn Mössbauer spectroscopy, in both Me2Sn(IV)fus2 and Bu2Sn(IV)fus2, trigonal bipyramidal configurations are proposed. NMR spectra, of both ligand and of the complexes were carried in DMSO-d6 solution, in which dialkyltin(IV)bis(fusidate) maintained their solid-state configuration. In vitro antimicrobial tests were performed on complexes, and good anti-staphylococcal activity was observed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.