The thus‐far unknown ureic derivative dimethyl 2,2′‐[carbonylbis(azanediyl)](2S,2′S)‐ bis[3‐(4‐hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available L‐tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO‐air).
Mancuso, R., Gioia, K.F., Palumbo Piccionello, A., Della Ca’, N., Carfagna, C., Gabriele, B. (2018). Dimethyl 2,2′‐[carbonylbis(Azanediyl)](2s,2′s)‐bis[3‐(4‐hydroxyphenyl)propanoate]. MOLBANK, 2018(1), M983 [10.3390/M983].
Dimethyl 2,2′‐[carbonylbis(Azanediyl)](2s,2′s)‐bis[3‐(4‐hydroxyphenyl)propanoate]
Palumbo Piccionello, Antonio;
2018-01-01
Abstract
The thus‐far unknown ureic derivative dimethyl 2,2′‐[carbonylbis(azanediyl)](2S,2′S)‐ bis[3‐(4‐hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available L‐tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO‐air).
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