Thrombosis is the most frequent complication and the second cause of death in patients with malignant disease. Primary central nervous system non-Hodgkin's lymphoma represents a rare pathology. Resistance to APC is usually linked to a factor V (FV) gene mutation changing an Arg 506 to a Gln in the APC cleavage site.
De Lucia, D., De Francesco, F., Marotta, R., Maisto, G., Meo, D., Sessa, M., et al. (2005). Phenotypic APC resistance as a marker of hypercoagulability in primitive cerebral lymphoma. EXPERIMENTAL ONCOLOGY, 27(2), 159-61.
Phenotypic APC resistance as a marker of hypercoagulability in primitive cerebral lymphoma
Napolitano, Mariasanta;
2005-01-01
Abstract
Thrombosis is the most frequent complication and the second cause of death in patients with malignant disease. Primary central nervous system non-Hodgkin's lymphoma represents a rare pathology. Resistance to APC is usually linked to a factor V (FV) gene mutation changing an Arg 506 to a Gln in the APC cleavage site.
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