Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogues

Fattizzo, B; Pasquale, R; Carpenedo, M; Cantoni, S; Auteri, G; Gramegna, D; D'Adda, M; Napolitano, M; Consonni, D; Ruggeri, M; Siragusa, S; Rossi, G; Vianelli, N; Barcellini, W

doi:10.3324/haematol.2019.216804

It is well established that immune thrombocytopenia (ITP) results from increased immune mediated platelet destruction (anti-platelets antibodies, autoreactive T cells, and reduction of regulatory T cells) along with impaired production in the bone marrow.1 The latter has been attributed to both cellular and humoral mediators that cause suppression of megakaryocyte production and maturation.2 Current standard first line therapy consists of corticosteroids, with or without intravenous Ig, achieving about 70-80% response rate. However, a consistent proportion of patients would relapse after corticosteroid discontinuation or tapering, and requires further therapy. ...

Fattizzo, B., Pasquale, R., Carpenedo, M., Cantoni, S., Auteri, G., Gramegna, D., et al. (2019). Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogues. HAEMATOLOGICA, 104, haematol.2019.216804.

Data di pubblicazione:	2019
Titolo:	Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogues
Autori:	Fattizzo, Bruno Pasquale, Raffaella Carpenedo, Monica Cantoni, Silvia Auteri, Giuseppe Gramegna, Doriana D'Adda, Mariella NAPOLITANO, Mariasanta Consonni, Dario Ruggeri, Marco SIRAGUSA, Sergio Rossi, Giuseppe Vianelli, Nicola Barcellini, Wilma mostra contributor esterni nascondi contributor esterni
Citazione:	Fattizzo, B., Pasquale, R., Carpenedo, M., Cantoni, S., Auteri, G., Gramegna, D., et al. (2019). Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogues. HAEMATOLOGICA, 104, haematol.2019.216804.
Rivista:	HAEMATOLOGICA
Digital Object Identifier (DOI):	http://dx.doi.org/10.3324/haematol.2019.216804
Appare nelle tipologie:	1.06 Lettera

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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/10447/348018

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