It is well established that immune thrombocytopenia (ITP) results from increased immune mediated platelet destruction (anti-platelets antibodies, autoreactive T cells, and reduction of regulatory T cells) along with impaired production in the bone marrow.1 The latter has been attributed to both cellular and humoral mediators that cause suppression of megakaryocyte production and maturation.2 Current standard first line therapy consists of corticosteroids, with or without intravenous Ig, achieving about 70-80% response rate. However, a consistent proportion of patients would relapse after corticosteroid discontinuation or tapering, and requires further therapy. ...
Fattizzo, B., Pasquale, R., Carpenedo, M., Cantoni, S., Auteri, G., Gramegna, D., et al. (2019). Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogues. HAEMATOLOGICA, 104, haematol.2019.216804 [10.3324/haematol.2019.216804].
Data di pubblicazione: | 2019 | |
Titolo: | Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogues | |
Autori: | ||
Citazione: | Fattizzo, B., Pasquale, R., Carpenedo, M., Cantoni, S., Auteri, G., Gramegna, D., et al. (2019). Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogues. HAEMATOLOGICA, 104, haematol.2019.216804 [10.3324/haematol.2019.216804]. | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.3324/haematol.2019.216804 | |
Appare nelle tipologie: | 1.06 Lettera |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
haematol.2019.216804.full.pdf | Artciolo pubblicato | N/A | Administrator Richiedi una copia | |
Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogues.pdf | Versione Editoriale | Administrator Richiedi una copia |