Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.

Purpose: To assess the accuracy of liver stiffness quantification in patients with non-alcoholic steatohepatitis (NASH) using shear wave elastography (SWE) in comparison with transient elastography (TE). Methods and Materials: This is a prospective study performed in a single institution, including 49 patients with histological diagnosis of NASH. The stiffness of the right liver lobe was measured on the same day with two techniques: TE (FibroScan, Echosens), and SWE (RS80A ultrasound system, Samsung Medison). In the SWE evaluation, 11 patients were excluded due to more than 75% measurements fails. Receiver operating curves (ROC), areas under the ROC (AUROC) and 95% confidence intervals (CI) were calculated to assess the accuracy of TE and SWE for the diagnosis of significant fibrosis (F2-F4) and advanced fibrosis (F3-F4). Spearman’s rank coefficient (rho) was used for correlation of TE with SWE. A p<0.05 was considered for statistical significance. Results: 38 patients were included in the final population. Overall 24 (63%) patients had significant fibrosis and 17 (45%) had advanced fibrosis. TE and SWE showed an AUROC of 0.711 (95% CI: 0.545-0.877, p=0.032) and 0.729 (95% CI: 0.562-0.896, p=0.020) for the diagnosis of significant fibrosis. The AUROC for the diagnosis of advanced fibrosis were 0.803 (95% CI: 0.648- 0.9580, p=0.002) and 0.811 (95% CI: 0.667-0.955, p=0.001) for TE and SWE, respectively. There was a significant correlation between TE and SWE measurements (rho=0.455, p = 0.004). Conclusion: SWE and TE have both a good accuracy, with a significant correlation, for the diagnosis of advanced fibrosis in NASH-patients.

Caruana, G., Taibbi, A., Petta, S., Cannella, R., Buse', G., Cutaia, G., et al. (2019). Liver stiffness quantification in patients with non-alcoholic steatohepatitis: comparison of shear wave elastography and transient elastography with liver biopsy correlation. In ECR 2019 Book of Abstract (pp.509-509). Vienna : Springer.

Powered by IRIS-about IRIS-Utilizzo dei cookie

 Copyright © 2022