Direct acting antivirals (DAAs) stabilize or improve liver function in the majority of patients with HCV cirrhosis. Hepatic decompensation is the main driver of death of patients with early, successfully treated HCC superimposed to cirrhosis . Treatment with DAAs could improve the prognosis of these subjects, independently from the subsequent course of HCC, if the efficacy in obtaining viral clearance is as high as in patients without a history of HCC, and if the risk of HCC recurrence is unaffected . When dealing with HCC patients, DAA s can be indicated in two different settings: a) subjects in which HCC has been already successfully treated (“cured” HCC), or b) subjects whose HCC is still untreated or untreatable (“active” HCC). While there are abundant data on “cured” HCC, evidence supporting treatment decisions in patients with “active” HCC is at best scarce and controversial, since these patients as well as patients with HCC listed for liver transplantation (LT) are usually excluded from treatment.

Cabibbo G, C.C. (2018). Should we cure hepatitis C virus in patients with hepatocellular carcinoma while treating cancer?. LIVER INTERNATIONAL, 38(12), 2108-2116 [10.1111/liv.13918].

Should we cure hepatitis C virus in patients with hepatocellular carcinoma while treating cancer?

Cabibbo G
;
Celsa C;Cammà C;Craxì A.
2018-01-01

Abstract

Direct acting antivirals (DAAs) stabilize or improve liver function in the majority of patients with HCV cirrhosis. Hepatic decompensation is the main driver of death of patients with early, successfully treated HCC superimposed to cirrhosis . Treatment with DAAs could improve the prognosis of these subjects, independently from the subsequent course of HCC, if the efficacy in obtaining viral clearance is as high as in patients without a history of HCC, and if the risk of HCC recurrence is unaffected . When dealing with HCC patients, DAA s can be indicated in two different settings: a) subjects in which HCC has been already successfully treated (“cured” HCC), or b) subjects whose HCC is still untreated or untreatable (“active” HCC). While there are abundant data on “cured” HCC, evidence supporting treatment decisions in patients with “active” HCC is at best scarce and controversial, since these patients as well as patients with HCC listed for liver transplantation (LT) are usually excluded from treatment.
2018
Cabibbo G, C.C. (2018). Should we cure hepatitis C virus in patients with hepatocellular carcinoma while treating cancer?. LIVER INTERNATIONAL, 38(12), 2108-2116 [10.1111/liv.13918].
File in questo prodotto:
File Dimensione Formato  
cabibbo2018.pdf

Solo gestori archvio

Dimensione 799.78 kB
Formato Adobe PDF
799.78 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/345379
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 18
social impact