Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.

Modica de Mohac, L., Keating, A., de Fátima Pina, M., Raimi-Abraham, B. (2018). Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery. PHARMACEUTICS, 11(1), 7 [10.3390/pharmaceutics11010007].

Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery

MODICA DE MOHAC, Laura
Writing – Original Draft Preparation
;
2018-01-01

Abstract

Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.
2018
Modica de Mohac, L., Keating, A., de Fátima Pina, M., Raimi-Abraham, B. (2018). Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery. PHARMACEUTICS, 11(1), 7 [10.3390/pharmaceutics11010007].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/332900
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