In this work, new micellar systems able to cross corneal barrier and to improve the permeation of imatinib free base were prepared and characterized. HA-EDA-C16, HA-EDA-C16−PEG, and HA-EDA-C16−CRN micelles were synthesized starting from hyaluronic acid (HA), ethylenediamine (EDA), hexadecyl chains (C16), polyethylene glycol (PEG), or L-carnitine (CRN). These nanocarriers showed optimal particle size and mucoadhesive properties. Imatinibloaded micelles were able to interact with corneal barrier and to promote imatinib transcorneal permeation and penetration. In addition, a study was conducted to understand the in vitro imatinib inhibitory effect on a choroidal neovascularization process. Imatinib released from polymeric micelles was able to inhibit endothelial cell sprouting and to promote cell tube disruption.
Flavia Bongiovì, C.F. (2018). Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases. MOLECULAR PHARMACEUTICS, 15(11), 5031-5045 [10.1021/acs.molpharmaceut.8b00620].
Data di pubblicazione: | 2018-11-05 | |
Titolo: | Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases | |
Autori: | PITARRESI, Giovanna (Corresponding) | |
Citazione: | Flavia Bongiovì, C.F. (2018). Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases. MOLECULAR PHARMACEUTICS, 15(11), 5031-5045 [10.1021/acs.molpharmaceut.8b00620]. | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/acs.molpharmaceut.8b00620 | |
Abstract: | In this work, new micellar systems able to cross corneal barrier and to improve the permeation of imatinib free base were prepared and characterized. HA-EDA-C16, HA-EDA-C16−PEG, and HA-EDA-C16−CRN micelles were synthesized starting from hyaluronic acid (HA), ethylenediamine (EDA), hexadecyl chains (C16), polyethylene glycol (PEG), or L-carnitine (CRN). These nanocarriers showed optimal particle size and mucoadhesive properties. Imatinibloaded micelles were able to interact with corneal barrier and to promote imatinib transcorneal permeation and penetration. In addition, a study was conducted to understand the in vitro imatinib inhibitory effect on a choroidal neovascularization process. Imatinib released from polymeric micelles was able to inhibit endothelial cell sprouting and to promote cell tube disruption. | |
URL dell'editore: | https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00620 | |
Settore Scientifico Disciplinare: | Settore CHIM/09 - Farmaceutico Tecnologico Applicativo | |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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