Guillain-Barrè Syndrome, as part of the spectrum of dysimmune neuropathies, is unexpected to occur in immunocompromised hosts. We describe a clinical case of Guillain-Barrè syndrome, occurred a few weeks after a liver transplant, and we postulate that our case would satisfy all requirements to explain this peripheral nervous system complication as a clinical manifestation of an Immune reconstitution inflammatory syndrome. In this setting of liver transplantation, complicated by potentially multiple infective triggers, reduction of immunosuppression and reversal of pathogen-induced immunosuppression, through antimicrobial therapy, may have led to pro-inflammatory response. The pro-inflammatory pattern would have sustained the pathophysiologic mechanism of this immune neuropathy.

Lo Re, V., Petridis, I., Živković, S., Burgio, G., Mularoni, A., Milazzo, M., et al. (2018). Guillain-Barré syndrome after orthotopic liver transplantation: A clinical manifestation of immune reconstitution inflammatory syndrome?. CLINICAL NEUROLOGY AND NEUROSURGERY, 173, 140-143 [10.1016/j.clineuro.2018.07.021].

Guillain-Barré syndrome after orthotopic liver transplantation: A clinical manifestation of immune reconstitution inflammatory syndrome?

Lo Re, Vincenzina
;
Petridis, Ioannis;Milazzo, Mariapina;Sparacia, Gianvincenzo;
2018

Abstract

Guillain-Barrè Syndrome, as part of the spectrum of dysimmune neuropathies, is unexpected to occur in immunocompromised hosts. We describe a clinical case of Guillain-Barrè syndrome, occurred a few weeks after a liver transplant, and we postulate that our case would satisfy all requirements to explain this peripheral nervous system complication as a clinical manifestation of an Immune reconstitution inflammatory syndrome. In this setting of liver transplantation, complicated by potentially multiple infective triggers, reduction of immunosuppression and reversal of pathogen-induced immunosuppression, through antimicrobial therapy, may have led to pro-inflammatory response. The pro-inflammatory pattern would have sustained the pathophysiologic mechanism of this immune neuropathy.
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Lo Re, V., Petridis, I., Živković, S., Burgio, G., Mularoni, A., Milazzo, M., et al. (2018). Guillain-Barré syndrome after orthotopic liver transplantation: A clinical manifestation of immune reconstitution inflammatory syndrome?. CLINICAL NEUROLOGY AND NEUROSURGERY, 173, 140-143 [10.1016/j.clineuro.2018.07.021].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/318691
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