Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.
|Data di pubblicazione:||2004|
|Titolo:||Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs|
|Autori:||LAVITRANO M; SMOLENSKI RT; MUSUMECI A; MACCHERINI M; SLOMINSKA E; DI FLORIO E; BRACCO A; MANCINI A; STASSI G; PATTI M; GIOVANNONI R; FROIO A; SIMEONE F; FORNI M; BACCI ML; D'ALISE G; COZZI E; OTTERBEIN LE; YACOUB MH; BACH FH; CALISE F|
|Tipologia:||Articolo su rivista|
|Citazione:||LAVITRANO M, SMOLENSKI RT, MUSUMECI A, MACCHERINI M, SLOMINSKA E, DI FLORIO E, et al. (2004). Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. THE FASEB JOURNAL, 2004, 1093-1095.|
|Digital Object Identifier (DOI):||10.1096/fj.03-0996fje|
|Appare nelle tipologie:||01 - Articolo su rivista|