Ruta chalepensis L. (Rutaceae) leaf extract was investigated for its chemical profile and antioxidant and hypoglycaemic properties. The antioxidant effects were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), Chi-carotene bleaching, and metal chelating activity assays. The carbohydrate-hydrolysing enzymes inhibition assay was used to test the hypoglycaemic potential. R. chalepensis showed a high content of hesperidin and rutin with values of 591.9 and 266.7 mg/g dry extract, respectively. The extract exhibited a promising protection of lipid peroxidation (IC50 value of 16.9 mu g/mL) and inhibited both alpha-amylase and alpha-glucosidase enzymes in a concentration-dependent manner. The highest activity was found against alpha-amylase (IC50 value of 69.0 mu g/mL). The obtained results support the use of R. chalepensis leaves as healthy food ingredients.

Loizzo, M., Falco, T., Bonesi, M., Sicari, V., Tundis, R., Bruno, M. (2018). Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition, antioxidant and hypoglicaemic activities. NATURAL PRODUCT RESEARCH, 32(5), 521-528 [10.1080/14786419.2017.1326491].

Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition, antioxidant and hypoglicaemic activities

Bruno, M
2018-01-01

Abstract

Ruta chalepensis L. (Rutaceae) leaf extract was investigated for its chemical profile and antioxidant and hypoglycaemic properties. The antioxidant effects were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), Chi-carotene bleaching, and metal chelating activity assays. The carbohydrate-hydrolysing enzymes inhibition assay was used to test the hypoglycaemic potential. R. chalepensis showed a high content of hesperidin and rutin with values of 591.9 and 266.7 mg/g dry extract, respectively. The extract exhibited a promising protection of lipid peroxidation (IC50 value of 16.9 mu g/mL) and inhibited both alpha-amylase and alpha-glucosidase enzymes in a concentration-dependent manner. The highest activity was found against alpha-amylase (IC50 value of 69.0 mu g/mL). The obtained results support the use of R. chalepensis leaves as healthy food ingredients.
2018
Settore CHIM/06 - Chimica Organica
Loizzo, M., Falco, T., Bonesi, M., Sicari, V., Tundis, R., Bruno, M. (2018). Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition, antioxidant and hypoglicaemic activities. NATURAL PRODUCT RESEARCH, 32(5), 521-528 [10.1080/14786419.2017.1326491].
File in questo prodotto:
File Dimensione Formato  
Ruta chalepensis.pdf

Solo gestori archvio

Dimensione 955.96 kB
Formato Adobe PDF
955.96 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/300285
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 32
  • ???jsp.display-item.citation.isi??? 27
social impact