Die Bedeutung von Magnesium für Insulinresistenz, metabolisches Syndrom und Diabetes mellitus - Empfehlungen der Gesellschaft für Magnesium-Forschung e.V

Magnesium (Mg) depletion is an important and high prevalent condition in patients with diabetes and precursor states of diabetes 2 like metabolic syndrome. Mg deficiency increases the risk of developing diabetes 2. These recommendations compile present data on the physiology of Mg in carbohydrate metabolism and pathopysiological consequences of Magnesium depletion for diabetics. Diabetes patients and candidates benefit from four categories of Mg-effects: insulin sensitizing effect, Ca antagonism, stress regulating and endothelium stabilizing effects. Clinical data with Mg comedication show improvement of insulin-resistance/blood glucose level and reduced long term vascular damages in surrogate parameters. High serum Mg is associated with lower prevalence of retinopathy, severity of retinopathy is associated with the degree of Mg depletion. High serum Mg is also associated with less deterioration of renal function in diabetics. Depression, a comorbiditity of diabetes, is less prevalent in patients with high serum Mg. A standardized regimen for diagnosing Mg-depletion and a regimen for supplementing these patients is outlined. Diagnosis of Mg depletion is simple predominantly by synoptic view of anamnestic, clinical or/and laboratory data.© Georg Thieme Verlag KG Stuttgart.New York.