In the last three decades, the constantly increasing need for therapies, efficiently preventing and/or treating human diseases, has raised the interest in Regenerative Medicine (RM). RM is based on employing mesenchymal stem cells (MSCs), that showed to have great proliferation, self-renewal and multilineage differentiation potential, in vitro as well as in vivo. The opportunity of an accessible, painless and low-cost reservoir of MSCs constitutes the first important step of a successful regenerative therapy to include in the current clinical practice. Oral cavity has recently demonstrated to contain different MSCs niches: dental pulp from permanent and deciduous teeth, periodontal ligament, dental follicle, apical papilla and mucosa. MSCs from dental pulp of deciduous teeth, naturally lost in pediatric age, and the oral mucosa have shown to be easily harvested and to have a promising regenerative potential. Thus, the aim of the paper is to review the potentialities of human exfoliated deciduous teeth stem cells (SHEDs) and oral mucosa stem cells (OMSCs) in RM, with the purpose of their use as accessible source of MSCs for the future of pediatric patient.

Marta Cristaldi, R.M. (2018). Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration. JOURNAL OF PEDIATRICS AND PEDIATRIC MEDICINE(3), 12-17.

Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration

Marta Cristaldi;Rodolfo Mauceri;Laura Tomasello;Giuseppe Pizzolanti;Giovanni Zito;Riccardo Alessandro;Carla Giordano
;
Giuseppina Campisi
2018

Abstract

In the last three decades, the constantly increasing need for therapies, efficiently preventing and/or treating human diseases, has raised the interest in Regenerative Medicine (RM). RM is based on employing mesenchymal stem cells (MSCs), that showed to have great proliferation, self-renewal and multilineage differentiation potential, in vitro as well as in vivo. The opportunity of an accessible, painless and low-cost reservoir of MSCs constitutes the first important step of a successful regenerative therapy to include in the current clinical practice. Oral cavity has recently demonstrated to contain different MSCs niches: dental pulp from permanent and deciduous teeth, periodontal ligament, dental follicle, apical papilla and mucosa. MSCs from dental pulp of deciduous teeth, naturally lost in pediatric age, and the oral mucosa have shown to be easily harvested and to have a promising regenerative potential. Thus, the aim of the paper is to review the potentialities of human exfoliated deciduous teeth stem cells (SHEDs) and oral mucosa stem cells (OMSCs) in RM, with the purpose of their use as accessible source of MSCs for the future of pediatric patient.
http://www.pediatricsresearchjournal.com/articles/human-exfoliated-deciduous-teeth-and-oral-mucosa-promising-applications-in-tissue-regeneration.html
Marta Cristaldi, R.M. (2018). Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration. JOURNAL OF PEDIATRICS AND PEDIATRIC MEDICINE(3), 12-17.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/297300
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