Among diseases whose cure is still far from being discovered, Alzheimer’s disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including the nature of protein misfolding, which results in the production of toxic species. Considering the involvement of (mis)folding processes in AD aetiology, targeting molecular chaperones represents a promising therapeutic perspective. This review analyses the connection between AD and molecular chaperones, with particular attention toward the most important heat shock proteins (HSPs) as representative components of the human chaperome: Hsp60, Hsp70 and Hsp90. The role of these proteins in AD is highlighted from a biological point of view. Pharmacological targeting of such HSPs with inhibitors or regulators is also discussed.

Campanella, C., Pace, A., Caruso Bavisotto, C., Marzullo, P., Marino Gammazza, A., Buscemi, S., et al. (2018). Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(9), 1-22 [10.3390/ijms19092603].

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

Campanella, Claudia
;
Pace, Andrea;Caruso Bavisotto, Celeste;Marzullo, Paola;Marino Gammazza, Antonella;Buscemi, Silvestre;Palumbo Piccionello, Antonio
2018-09-01

Abstract

Among diseases whose cure is still far from being discovered, Alzheimer’s disease (AD) has been recognized as a crucial medical and social problem. A major issue in AD research is represented by the complexity of involved biochemical pathways, including the nature of protein misfolding, which results in the production of toxic species. Considering the involvement of (mis)folding processes in AD aetiology, targeting molecular chaperones represents a promising therapeutic perspective. This review analyses the connection between AD and molecular chaperones, with particular attention toward the most important heat shock proteins (HSPs) as representative components of the human chaperome: Hsp60, Hsp70 and Hsp90. The role of these proteins in AD is highlighted from a biological point of view. Pharmacological targeting of such HSPs with inhibitors or regulators is also discussed.
1-set-2018
Campanella, C., Pace, A., Caruso Bavisotto, C., Marzullo, P., Marino Gammazza, A., Buscemi, S., et al. (2018). Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(9), 1-22 [10.3390/ijms19092603].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/296837
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