The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents.

Graziano, F., Caruso, C., Marino Gammazza, A., Rappa, F., de Macario, E.C., Macario, A.J.L., et al. (2018). Chaperonology: The third eye on brain gliomas. BRAIN SCIENCES, 8(6), 110 [10.3390/brainsci8060110].

Chaperonology: The third eye on brain gliomas

Graziano, Francesca;Caruso, C.;Marino Gammazza, A;Rappa, Francesca;Cappello, Francesco;Campanella, Claudia;Iacopino, Domenico Gerardo
2018-01-01

Abstract

The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents.
2018
Graziano, F., Caruso, C., Marino Gammazza, A., Rappa, F., de Macario, E.C., Macario, A.J.L., et al. (2018). Chaperonology: The third eye on brain gliomas. BRAIN SCIENCES, 8(6), 110 [10.3390/brainsci8060110].
File in questo prodotto:
File Dimensione Formato  
Graziano f et al brainsci-08-00110.pdf

accesso aperto

Dimensione 906.75 kB
Formato Adobe PDF
906.75 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/295724
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 15
social impact