Drug-induced liver injury (DILI) remains the most common cause of acute liver failure in the Western world. Chemotherapy is one of the major class of drugs most frequently associated with idiosyncratic DILI. For this reason, patients who receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate and which drug doses should be modified. S-adenosylmethionine (SAMe) is an endogenous agent derived from methionine. Its supplementation is effective in the treatment of liver disease, in particular intrahepatic cholestasis (IHC). The target of this review is to analyze the mechanisms of hepatotoxicity of the principal anticancer agents and the role of SAMe in the prevention of this complication.

Vincenzi, B., Russo, A., Terenzio, A., Galvano, A., Santini, D., Vorini, F., et al. (2018). The use of same in chemotherapy-induced liver injury. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 130, 70-77 [10.1016/j.critrevonc.2018.06.019].

The use of same in chemotherapy-induced liver injury

Russo, A.;Galvano, A.;Santini, D.;
2018-01-01

Abstract

Drug-induced liver injury (DILI) remains the most common cause of acute liver failure in the Western world. Chemotherapy is one of the major class of drugs most frequently associated with idiosyncratic DILI. For this reason, patients who receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate and which drug doses should be modified. S-adenosylmethionine (SAMe) is an endogenous agent derived from methionine. Its supplementation is effective in the treatment of liver disease, in particular intrahepatic cholestasis (IHC). The target of this review is to analyze the mechanisms of hepatotoxicity of the principal anticancer agents and the role of SAMe in the prevention of this complication.
2018
Settore MED/06 - Oncologia Medica
Vincenzi, B., Russo, A., Terenzio, A., Galvano, A., Santini, D., Vorini, F., et al. (2018). The use of same in chemotherapy-induced liver injury. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 130, 70-77 [10.1016/j.critrevonc.2018.06.019].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/295512
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