Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly
Lombardo, V., Puccia, F., Terranova, A., Affronti, A., Florena, A., Giannitrapani, L., et al. (2018). Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report. ITALIAN JOURNAL OF MEDICINE, 12(1), 61-66 [10.4081/itjm.2018.932].
Data di pubblicazione: | 2018 | |
Titolo: | Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report | |
Autori: | ||
Citazione: | Lombardo, V., Puccia, F., Terranova, A., Affronti, A., Florena, A., Giannitrapani, L., et al. (2018). Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report. ITALIAN JOURNAL OF MEDICINE, 12(1), 61-66 [10.4081/itjm.2018.932]. | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.4081/itjm.2018.932 | |
Abstract: | Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly | |
URL: | http://italjmed.org/index.php/ijm/article/view/itjm.2018.932/1064 | |
Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna | |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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