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EnglishHemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly
Lombardo, V., Puccia, F., Terranova, A., Affronti, A., Florena, A., Giannitrapani, L., et al. (2018). Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report. ITALIAN JOURNAL OF MEDICINE, 12(1), 61-66.
| Data di pubblicazione: | 2018 |
| Titolo: | Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report |
| Autori: | |
| Citazione: | Lombardo, V., Puccia, F., Terranova, A., Affronti, A., Florena, A., Giannitrapani, L., et al. (2018). Hemophagocytic syndrome in a patient with disseminated tuberculosis: A case report. ITALIAN JOURNAL OF MEDICINE, 12(1), 61-66. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.4081/itjm.2018.932 |
| Abstract: | Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma revealed a HS. The bronchoalveolar lavage (BAL) culture was then positive for MT and subsequently, radiologic aspects of lung and spleen TB involvement appeared. A disseminated tuberculosis was diagnosed. Despite antituberculous therapy, the patient died as in approximately 50% of the HS associated with TB. nly |
| URL: | http://italjmed.org/index.php/ijm/article/view/itjm.2018.932/1064 |
| Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| It J Med HS TBC.pdf | N/A | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/288849
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