IAPs (inhibitors of apoptosis proteins) might have a major role in the apoptotic resistance that marks many cancers. The studies on IAPs in human HCC have focused on survivin or XIAP, indicating that their new or increased expression in this tumor is associated with a more unfavorable prognosis. The present results corroborate these findings, emphasizing the role that the coordinated expression of different IAPs and alternative splice variants might play in the adverse biology of hepatocellular carcinoma.
NOTARBARTOLO DI VILLAROSA, M., CERVELLO, M., GIANNITRAPANI, L., MELI, M., POMA, P., DUSONCHET, L., et al. (2004). Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1028, 289-293.
Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells
NOTARBARTOLO DI VILLAROSA, Monica;GIANNITRAPANI, Lydia;MELI, Maria;POMA, Paola;DUSONCHET, Luisa;MONTALTO, Giuseppe;D'ALESSANDRO, Natale
2004-01-01
Abstract
IAPs (inhibitors of apoptosis proteins) might have a major role in the apoptotic resistance that marks many cancers. The studies on IAPs in human HCC have focused on survivin or XIAP, indicating that their new or increased expression in this tumor is associated with a more unfavorable prognosis. The present results corroborate these findings, emphasizing the role that the coordinated expression of different IAPs and alternative splice variants might play in the adverse biology of hepatocellular carcinoma.
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