PHA is a rare cause of hydramnios, characterized by increased amniotic fluid levels of aldosterone and sodium. Two distinct genetic entities (PHA type I and PHA type II) are included. Both are stemmed by a target organ defect with diminished renal tubular responsiveness to aldosterone. The AA present a case in which pregnancy resulted in a preterm infant with severe hydramnios, metabolic acidosis, hyponatriemia, hyperkaliemia. Salt and fluid replacement significantly improved clinical and metabolic condition. However a growth deficiency (-2 SDS) persists at follow-up
LIOTTA A, MAGGIO MC, IACHININOTO R, BELLIPANNI PF, CALI G, ARENA V, et al. (2004). Fetal pseudohypoaldosteronism: rare cause of hydramnios. PEDIATRIA MEDICA E CHIRURGICA, 26(2), 145-147.
Fetal pseudohypoaldosteronism: rare cause of hydramnios
MAGGIO, Maria Cristina;ARENA, Vincenzo;
2004-01-01
Abstract
PHA is a rare cause of hydramnios, characterized by increased amniotic fluid levels of aldosterone and sodium. Two distinct genetic entities (PHA type I and PHA type II) are included. Both are stemmed by a target organ defect with diminished renal tubular responsiveness to aldosterone. The AA present a case in which pregnancy resulted in a preterm infant with severe hydramnios, metabolic acidosis, hyponatriemia, hyperkaliemia. Salt and fluid replacement significantly improved clinical and metabolic condition. However a growth deficiency (-2 SDS) persists at follow-up
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