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EnglishOBJECTIVES: To evaluate in a retrospective analysis the efficacy and safety of a 6 day course of liposomal amphotericin B (L-AmB) in infantile cases of Mediterranean visceral leishmaniasis (VL) diagnosed over a 10 year period in Italy. PATIENTS AND METHODS: Patients included were diagnosed as having VL consecutively admitted from December 1992 to December 2001 at four main referral children's hospitals in Italy and treated with six intravenous doses of 3 mg/kg L-AmB given on days 1-5 and 10 (a total dose of 18 mg/kg). Demographic data, nutritional status, underlying diseases, clinical and laboratory findings, and therapy outcome were considered. RESULTS: A total of 164 HIV-negative children (median age 1.6 years; range 4 months to 14 years) were enrolled. All patients were initially cured by the given treatment, and did not present adverse events related to drug infusion. Seven patients (4.3%) had a clinical and parasitological relapse 3-15 months after therapy. All relapses were successfully retreated with 3 mg/kg L-AmB for 10 consecutive days (a total dose of 30 mg/kg). CONCLUSIONS: This study highlights the efficacy (>95%) and safety of the six dose L-AmB regimen and validates it as a first-line treatment for Mediterranean VL in children.
Cascio, A., Di Martino, L., Occorsio, P., Giacchino, R., Catania, S., Gigliotti, A., et al. (2004). A 6 day course of liposomal amphotericin B in the treatment of infantile visceral leishmaniasis: the Italian experience. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 54, 217-220.
| Data di pubblicazione: | 2004 | |
| Titolo: | A 6 day course of liposomal amphotericin B in the treatment of infantile visceral leishmaniasis: the Italian experience | |
| Autori: | ||
| Citazione: | Cascio, A., Di Martino, L., Occorsio, P., Giacchino, R., Catania, S., Gigliotti, A., et al. (2004). A 6 day course of liposomal amphotericin B in the treatment of infantile visceral leishmaniasis: the Italian experience. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 54, 217-220. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/JAC/DKH279 | |
| Abstract: | OBJECTIVES: To evaluate in a retrospective analysis the efficacy and safety of a 6 day course of liposomal amphotericin B (L-AmB) in infantile cases of Mediterranean visceral leishmaniasis (VL) diagnosed over a 10 year period in Italy. PATIENTS AND METHODS: Patients included were diagnosed as having VL consecutively admitted from December 1992 to December 2001 at four main referral children's hospitals in Italy and treated with six intravenous doses of 3 mg/kg L-AmB given on days 1-5 and 10 (a total dose of 18 mg/kg). Demographic data, nutritional status, underlying diseases, clinical and laboratory findings, and therapy outcome were considered. RESULTS: A total of 164 HIV-negative children (median age 1.6 years; range 4 months to 14 years) were enrolled. All patients were initially cured by the given treatment, and did not present adverse events related to drug infusion. Seven patients (4.3%) had a clinical and parasitological relapse 3-15 months after therapy. All relapses were successfully retreated with 3 mg/kg L-AmB for 10 consecutive days (a total dose of 30 mg/kg). CONCLUSIONS: This study highlights the efficacy (>95%) and safety of the six dose L-AmB regimen and validates it as a first-line treatment for Mediterranean VL in children. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/10447/27165
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