Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by β-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/β-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.

Deschene, E., Myung, P., Rompolas, P., Zito, G., Sun, T., Taketo, M., et al. (2014). β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. SCIENCE, 343(6177), 1353-1356 [10.1126/science.1248373].

β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche

Zito, Giovanni;
2014

Abstract

Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by β-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/β-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.
http://www.sciencemag.org/content/343/6177/1353.full.pdf
Deschene, E., Myung, P., Rompolas, P., Zito, G., Sun, T., Taketo, M., et al. (2014). β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. SCIENCE, 343(6177), 1353-1356 [10.1126/science.1248373].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/253992
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