Fish are equipped with a complex lectin repertoire that, like mammals, are involved almost all the immune reactions. Carbohydrate recognition and interactions mediated by lectins have been recognized involved in vertebrate innate immunity, not only for recognition of potential pathogens, but also acting in the agglutination, immobilization and other functional steps. Fish are equipped with a complex lectin repertoire that, like mammals, are involved almost all the immune reactions. Carbohydrate recognition and interactions mediated by lectins have been recognized involved in vertebrate innate immunity, not only for recognition of potential pathogens, but also acting in the agglutination, immobilization and other functional steps. In fish, C and F types lectins, galectins, rhamnose-binding lectin (RBL) and pentraxin have been identified in both in both cartilaginous and bony fish. In addition, selectins and other genes have been found in the currently available fish genomes. On the basis of our results on F-type (FBL) and RBL lectins we showed that: -lectin repertoires in fish are highly diversified and include not only representatives of the lectin families; described in mammals, but also members of lectin families described for the first time in fish species like the FBL and RBL; -these lectins have been identified in the eggs and embryos but also are present in the serum; -tissue-specific expression and localization of the diverse lectin repertoires and their molecular partners is consistent with their distinct biological roles in innate and adaptive immunity; -although some lectins may bind endogenous ligands, others bind sugars on the surface of potential pathogens; in addition to pathogen recognition and opsonization, some lectins display additional effector roles, such as regulation of immune functions.

Cammarata, M., Parisi Maria Giovanna, (2017). Diversity evolution and immune function of fish lectins. INVERTEBRATE SURVIVAL JOURNAL, 14, 47-47.

Diversity evolution and immune function of fish lectins

Cammarata Matteo;Parisi Maria Giovanna
2017-01-01

Abstract

Fish are equipped with a complex lectin repertoire that, like mammals, are involved almost all the immune reactions. Carbohydrate recognition and interactions mediated by lectins have been recognized involved in vertebrate innate immunity, not only for recognition of potential pathogens, but also acting in the agglutination, immobilization and other functional steps. Fish are equipped with a complex lectin repertoire that, like mammals, are involved almost all the immune reactions. Carbohydrate recognition and interactions mediated by lectins have been recognized involved in vertebrate innate immunity, not only for recognition of potential pathogens, but also acting in the agglutination, immobilization and other functional steps. In fish, C and F types lectins, galectins, rhamnose-binding lectin (RBL) and pentraxin have been identified in both in both cartilaginous and bony fish. In addition, selectins and other genes have been found in the currently available fish genomes. On the basis of our results on F-type (FBL) and RBL lectins we showed that: -lectin repertoires in fish are highly diversified and include not only representatives of the lectin families; described in mammals, but also members of lectin families described for the first time in fish species like the FBL and RBL; -these lectins have been identified in the eggs and embryos but also are present in the serum; -tissue-specific expression and localization of the diverse lectin repertoires and their molecular partners is consistent with their distinct biological roles in innate and adaptive immunity; -although some lectins may bind endogenous ligands, others bind sugars on the surface of potential pathogens; in addition to pathogen recognition and opsonization, some lectins display additional effector roles, such as regulation of immune functions.
2017
XVIIIth scientific meeting of the Italian Association of Developmental and Comparative Immunobiology (IADCI)
Viterbo, Italy
8 - 10 February 2017
18
Cammarata, M., Parisi Maria Giovanna, (2017). Diversity evolution and immune function of fish lectins. INVERTEBRATE SURVIVAL JOURNAL, 14, 47-47.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/253507
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