Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.
EnglishThe state of melatonin confined in dry cholesterol/lecithin mixed reversed micelles dispersed in CCl4 was investigated using H-1-NMR and FT-IR spectroscopies as a function of the melatonin to lecithin molar ratio (R-MLT) and of the cholesterol to lecithin molar ratio (R-CHL). An analysis of experimental results leads to the hypothesis that, independent of R-MLT and as a consequence of anisotropic melatonin/lecithin, melatonin/cholesterol and cholesterol/lecithin interactions, melatonin is totally solubilized in reversed micelles. Melatonin is mainly located in and oriented in the nanodomain constituted by the hydrophilic groups of cholesterol and lecithin. A competition of melatonin and cholesterol for the hydrophilic binding sites of the reversed micelles was observed by changing the R-CHL. Some possible biological implications of the specific interactions governing the solubilization process, the preferential location and the peculiar properties of melatonin confined in cholesterol/lecithin mixed reversed micelles are discussed.
Bongiorno, D., Ceraulo, L., Ferrugia, M., Filizzola, F., Ruggirello, A., & TURCO LIVERI, V. (2005). Localization and Interactions of Melatonin in Dry Cholesterol/Lecithin Mixed Reversed Micelles used as Cell Membrane Models. JOURNAL OF PINEAL RESEARCH, 38, 292-298.
| Data di pubblicazione: | 2005 |
| Titolo: | Localization and Interactions of Melatonin in Dry Cholesterol/Lecithin Mixed Reversed Micelles used as Cell Membrane Models |
| Autori: | |
| Citazione: | Bongiorno, D., Ceraulo, L., Ferrugia, M., Filizzola, F., Ruggirello, A., & TURCO LIVERI, V. (2005). Localization and Interactions of Melatonin in Dry Cholesterol/Lecithin Mixed Reversed Micelles used as Cell Membrane Models. JOURNAL OF PINEAL RESEARCH, 38, 292-298. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1600-079X.2005.00211.x |
| Abstract: | The state of melatonin confined in dry cholesterol/lecithin mixed reversed micelles dispersed in CCl4 was investigated using H-1-NMR and FT-IR spectroscopies as a function of the melatonin to lecithin molar ratio (R-MLT) and of the cholesterol to lecithin molar ratio (R-CHL). An analysis of experimental results leads to the hypothesis that, independent of R-MLT and as a consequence of anisotropic melatonin/lecithin, melatonin/cholesterol and cholesterol/lecithin interactions, melatonin is totally solubilized in reversed micelles. Melatonin is mainly located in and oriented in the nanodomain constituted by the hydrophilic groups of cholesterol and lecithin. A competition of melatonin and cholesterol for the hydrophilic binding sites of the reversed micelles was observed by changing the R-CHL. Some possible biological implications of the specific interactions governing the solubilization process, the preferential location and the peculiar properties of melatonin confined in cholesterol/lecithin mixed reversed micelles are discussed. |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Bongiorno_et_al2005.pdf | Articolo | N/A | Administrator Richiedi una copia |
Copyright © 2021