Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallmark INT-0116 trial, minimal progress has been made both in terms of effectiveness and toxicity. Moreover, new regimens added to combined therapy failed to prove favourable results. Herein, we attempt a thorough literature review comparing pros and cons of all relative studies and potential bias, targeting well-designed future approaches.

Papadimitriou, K., Antoniou, G., Rolfo, C., Russo, A., Bronte, G., Vassiliou, V., et al. (2015). Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward. GASTROENTEROLOGY RESEARCH AND PRACTICE, 2015 [10.1155/2015/650846].

Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward

Papadimitriou, Konstantinos;Rolfo, Christian;Russo, Antonio;Bronte, Giuseppe;
2015

Abstract

Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallmark INT-0116 trial, minimal progress has been made both in terms of effectiveness and toxicity. Moreover, new regimens added to combined therapy failed to prove favourable results. Herein, we attempt a thorough literature review comparing pros and cons of all relative studies and potential bias, targeting well-designed future approaches.
http://www.hindawi.com/journals/grp/
Papadimitriou, K., Antoniou, G., Rolfo, C., Russo, A., Bronte, G., Vassiliou, V., et al. (2015). Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward. GASTROENTEROLOGY RESEARCH AND PRACTICE, 2015 [10.1155/2015/650846].
File in questo prodotto:
File Dimensione Formato  
Adjuvant Chemoradiation Therapy in Gastric Cancer Critically Reviewing the Past and Visualizing the Next Step Forward.pdf

accesso aperto

Dimensione 557.1 kB
Formato Adobe PDF
557.1 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/249790
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact