Sound-induced flash illusions depend on visual cortical excitability. In this study, we explored whether sound-induced flash illusions are perceived differently in migraine, a condition associated with pathologic cortical hyperexcitability. Methods: Sound-induced flash illusions were examined in 59 migraine patients (mean age 32 ± 16 years; 36 females), 32 without aura and 27 with aura, and in 24 healthy controls (mean age 42 ± 17 years; 16 females). Patients were studied during attacks and interictally. Visual stimuli (flashes) accompanied by sounds (beeps) were presented in different combinations: a single flash with multiple beeps was given to induce the perception of multiple flashes ("fission" illusion), and multiple flashes with a single beep were used to reduce the number of perceived flashes ("fusion" illusion). Results: For migraineurs, the fission illusion was reduced, especially during the attack, and almost abolished when a single flash was combined with 2 beeps (except for those without aura tested interictally); the fusion illusion was less consistently reported in both migraine groups, but not completely disrupted. Conclusions: Results from this study add novel clues to our understanding of visual cortex hyperexcitability in migraine, especially migraine with aura. Furthermore, these analyses underscore how pathologic changes in cortical excitability affect multisensory interactions. Cross-modal illusions represent a valid tool for exploration of functional connectivity between sensory areas, which likely has an important role in the pathophysiology of migraine.

Brighina, F., Bolognini, N., Cosentino, G., Maccora, S., Paladino, P., Baschi, R., et al. (2015). Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions. NEUROLOGY, 84(20), 2057-2061 [10.1212/WNL.0000000000001584].

Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions

Brighina, Filippo;Cosentino, Giuseppe;Paladino, Piera;Baschi, Roberta;Fierro, Brigida
2015

Abstract

Sound-induced flash illusions depend on visual cortical excitability. In this study, we explored whether sound-induced flash illusions are perceived differently in migraine, a condition associated with pathologic cortical hyperexcitability. Methods: Sound-induced flash illusions were examined in 59 migraine patients (mean age 32 ± 16 years; 36 females), 32 without aura and 27 with aura, and in 24 healthy controls (mean age 42 ± 17 years; 16 females). Patients were studied during attacks and interictally. Visual stimuli (flashes) accompanied by sounds (beeps) were presented in different combinations: a single flash with multiple beeps was given to induce the perception of multiple flashes ("fission" illusion), and multiple flashes with a single beep were used to reduce the number of perceived flashes ("fusion" illusion). Results: For migraineurs, the fission illusion was reduced, especially during the attack, and almost abolished when a single flash was combined with 2 beeps (except for those without aura tested interictally); the fusion illusion was less consistently reported in both migraine groups, but not completely disrupted. Conclusions: Results from this study add novel clues to our understanding of visual cortex hyperexcitability in migraine, especially migraine with aura. Furthermore, these analyses underscore how pathologic changes in cortical excitability affect multisensory interactions. Cross-modal illusions represent a valid tool for exploration of functional connectivity between sensory areas, which likely has an important role in the pathophysiology of migraine.
http://www.neurology.org
Brighina, F., Bolognini, N., Cosentino, G., Maccora, S., Paladino, P., Baschi, R., et al. (2015). Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions. NEUROLOGY, 84(20), 2057-2061 [10.1212/WNL.0000000000001584].
File in questo prodotto:
File Dimensione Formato  
89.Brighina et al Neurology 2015.pdf

Solo gestori archvio

Descrizione: articolo principale
Dimensione 252.64 kB
Formato Adobe PDF
252.64 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/249775
Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 0
social impact