Copper(II) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, 1H, and 12C NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [CuII (2-BZPH)2] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [CuII (2-BZPH)2] and [PtII (2-BZPH)2] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10µM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10 µM. While the PtII complexes may have damaged DNA to induce cell death, treatment with the CuII complex did not induce Jurkat cell death.
|Data di pubblicazione:||2004|
|Titolo:||Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpirrole and X-ray structure of bis[2-benzoylpirrolato(N,O)]copper (II).|
|Autori:||RUBINO S; PETRUSO S; PIERATTELLI R; BRUNO G; STOCCO G; STEARDO L; MOTTA M; PASSEROTTO M; DEL GIUDICE E; GULI G|
|Tipologia:||Articolo su rivista|
|Citazione:||RUBINO S, PETRUSO S, PIERATTELLI R, BRUNO G, STOCCO G, STEARDO L, et al. (2004). Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpirrole and X-ray structure of bis[2-benzoylpirrolato(N,O)]copper (II). JOURNAL OF INORGANIC BIOCHEMISTRY, 98(12), 2071-2079.|
|Digital Object Identifier (DOI):||10.1016/J.JIORGBIO.2004.09.012|
|Appare nelle tipologie:||01 - Articolo su rivista|