Few studies have investigated the influence of age on the relationships between systemic vascular damage, kidney dysfunction, and intrarenal hemodynamic changes in patients with hypertension without overt cardiovascular disease. The authors enrolled 126 elderly patients with hypertension (aged ≥65 years) and 350 nonelderly patients with hypertension (aged <65 years). Carotid intima-media thickness, renal resistive index, and aortic pulse wave velocity were performed in all patients. Elderly patients with hypertension had lower estimated glomerular filtration rates and higher albuminuria, renal resistive index, carotid intima-media thickness, and aortic pulse wave velocity compared with nonelderly patients with hypertension (P < .001). Carotid intima-media thickness independently correlated with renal resistive index and estimated glomerular filtration rate in nonelderly patients with hypertension, whereas it was significantly related to renal resistive index only in elderly patients with hypertension. Aortic pulse wave velocity was independently associated with albuminuria in nonelderly patients with hypertension, whereas it did not independently correlate with any indexes of renal damage in elderly patients with hypertension. Age is an important modifier of the relationships between renal function and renal hemodynamics with subclinical vascular involvement in elderly persons without cardiovascular disease.

Geraci, G., Mulè, G., Gabriella, P., Zammuto, M., Castiglia, A., Scaduto, E., et al. (2017). Relationship between kidney findings and systemic vascular damage in elderly hypertensive patients without overt cardiovascular disease. THE JOURNAL OF CLINICAL HYPERTENSION, 19(12), 1339-1347 [10.1111/jch.13127].

Relationship between kidney findings and systemic vascular damage in elderly hypertensive patients without overt cardiovascular disease

Geraci, Giulio
Writing – Original Draft Preparation
;
Mulè, Giuseppe
Writing – Review & Editing
;
Paladino, Gabriella
Investigation
;
Castiglia, Antonella
Investigation
;
Zotta, Federica
Investigation
;
Geraci, Calogero
Resources
;
Mansueto, Pasquale
Investigation
;
Cottone, Santina
Conceptualization
2017

Abstract

Few studies have investigated the influence of age on the relationships between systemic vascular damage, kidney dysfunction, and intrarenal hemodynamic changes in patients with hypertension without overt cardiovascular disease. The authors enrolled 126 elderly patients with hypertension (aged ≥65 years) and 350 nonelderly patients with hypertension (aged <65 years). Carotid intima-media thickness, renal resistive index, and aortic pulse wave velocity were performed in all patients. Elderly patients with hypertension had lower estimated glomerular filtration rates and higher albuminuria, renal resistive index, carotid intima-media thickness, and aortic pulse wave velocity compared with nonelderly patients with hypertension (P < .001). Carotid intima-media thickness independently correlated with renal resistive index and estimated glomerular filtration rate in nonelderly patients with hypertension, whereas it was significantly related to renal resistive index only in elderly patients with hypertension. Aortic pulse wave velocity was independently associated with albuminuria in nonelderly patients with hypertension, whereas it did not independently correlate with any indexes of renal damage in elderly patients with hypertension. Age is an important modifier of the relationships between renal function and renal hemodynamics with subclinical vascular involvement in elderly persons without cardiovascular disease.
Settore MED/09 - Medicina Interna
Settore MED/14 - Nefrologia
http://onlinelibrary.wiley.com/store/10.1111/jch.13127/asset/jch13127.pdf?v=1&t=jazrowag&s=56e58d45e559e5bcfd576d834d27f00ffd721923
Geraci, G., Mulè, G., Gabriella, P., Zammuto, M., Castiglia, A., Scaduto, E., et al. (2017). Relationship between kidney findings and systemic vascular damage in elderly hypertensive patients without overt cardiovascular disease. THE JOURNAL OF CLINICAL HYPERTENSION, 19(12), 1339-1347 [10.1111/jch.13127].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/249473
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