A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IR signaling are involved in brain cognitive functions and their dysfunction is implicated in Alzheimer’s disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim we have designed, synthesized and characterized a nanogel system (NG) that has been conjugated to insulin molecules (NG-In) to deliver the protein into the brain, as a tool for the development of a new therapy against AD. In our preclinical study in mice, intraperitoneal injection of fluorescentlabeled NG has allowed to determine the biodistribution of NG vs time in the whole body and its clearance through the kidneys and bladder. Furthermore, we have observed that mice injected with nanogel did not experience stress, discomfort, nor mortalities have been recorded during the observation time
Giacomazza, D., Picone, P., Ditta, L., Sabatino, M., Militello, V., Luigi San Biagio, P., et al. (2017). Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer’s Disease. BIOPHYSICAL JOURNAL, 112(3).
Data di pubblicazione: | 2017 |
Titolo: | Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer’s Disease |
Autori: | |
Citazione: | Giacomazza, D., Picone, P., Ditta, L., Sabatino, M., Militello, V., Luigi San Biagio, P., et al. (2017). Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer’s Disease. BIOPHYSICAL JOURNAL, 112(3). |
Rivista: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.bpj.2016.11.757 |
Nome del convegno: | 61st Annual Meeting of the Biophysical-Society |
Anno del convegno: | FEB 11-15, 2017 |
Settore Scientifico Disciplinare: | Settore CHIM/07 - Fondamenti Chimici Delle Tecnologie Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin) Settore BIO/09 - Fisiologia |
Appare nelle tipologie: | 1.05 Abstract in atti di convegno pubblicato in rivista |
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