Cancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this study was to identify novel CSC-targeting strategies.

Manic, G., Signore, M., Sistigu, A., Russo, G., Corradi, F., Siteni, S., et al. (2018). CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells. GUT, 67(5), 903-917 [10.1136/gutjnl-2016-312623].

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

Di Franco, Simone;Stassi, Giorgio;
2018-01-01

Abstract

Cancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this study was to identify novel CSC-targeting strategies.
2018
GUT
Manic, G., Signore, M., Sistigu, A., Russo, G., Corradi, F., Siteni, S., et al. (2018). CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells. GUT, 67(5), 903-917 [10.1136/gutjnl-2016-312623].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/245924
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