MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.
Guggino, G., Liberto, D., Pizzo, M., Saieva, L., Alessandro, R., Dieli, F., et al. (2017). IL-17 polarization of MAIT cells is derived from the activation of two different pathways. EUROPEAN JOURNAL OF IMMUNOLOGY, 47(11), 2002-2003 [10.1002/eji.201747140].
IL-17 polarization of MAIT cells is derived from the activation of two different pathways
Guggino, Giuliana;Saieva, Laura;Alessandro, Riccardo;Dieli, Francesco;Triolo, Giovanni;Ciccia, Francesco
2017-01-01
Abstract
MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.
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