It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic responses through changes in gene transcription outcomes. Environmental stress endured by individual organisms can also enforce epigenetic variations in offspring that had never experienced it directly, which is termed transgenerational inheritance. To date, research in the environmental epigenetics discipline has used a wide range of both model and non-model organisms to elucidate the various epigenetic mechanisms underlying the adaptive response to environmental stimuli. In this review, we discuss the advantages of the zebrafish model for studying how environmental toxicant exposures affect the regulation of epigenetic processes, especially DNA methylation, which is the best-studied epigenetic mechanism. We include several very recent studies describing the state-of-the-art knowledge on this topic in zebrafish, together with key concepts in the function of DNA methylation during vertebrate embryogenesis.

Cavalieri, V., Spinelli, G. (2017). Environmental epigenetics in zebrafish. EPIGENETICS & CHROMATIN, 10(1), 1-11 [10.1186/s13072-017-0154-0].

Environmental epigenetics in zebrafish

CAVALIERI, Vincenzo
;
SPINELLI, Giovanni
2017-10-05

Abstract

It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic responses through changes in gene transcription outcomes. Environmental stress endured by individual organisms can also enforce epigenetic variations in offspring that had never experienced it directly, which is termed transgenerational inheritance. To date, research in the environmental epigenetics discipline has used a wide range of both model and non-model organisms to elucidate the various epigenetic mechanisms underlying the adaptive response to environmental stimuli. In this review, we discuss the advantages of the zebrafish model for studying how environmental toxicant exposures affect the regulation of epigenetic processes, especially DNA methylation, which is the best-studied epigenetic mechanism. We include several very recent studies describing the state-of-the-art knowledge on this topic in zebrafish, together with key concepts in the function of DNA methylation during vertebrate embryogenesis.
5-ott-2017
Settore BIO/11 - Biologia Molecolare
Cavalieri, V., Spinelli, G. (2017). Environmental epigenetics in zebrafish. EPIGENETICS & CHROMATIN, 10(1), 1-11 [10.1186/s13072-017-0154-0].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/245213
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