One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.

Carini, F., Mazzola, M., Rappa, F., Jurjus, A., Gerges Geagea, A., Al Kattar, S., et al. (2017). COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS [10.21873/anticanres.11882].

COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS

CARINI, Francesco;RAPPA, Francesca;LEONE, Angelo;TOMASELLO, Giovanni
2017-01-01

Abstract

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.
Settore MED/18 - Chirurgia Generale
Settore MED/06 - Oncologia Medica
http://ar.iiarjournals.org/content/37/9/4759.full.pdf
Carini, F., Mazzola, M., Rappa, F., Jurjus, A., Gerges Geagea, A., Al Kattar, S., et al. (2017). COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS [10.21873/anticanres.11882].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/242104
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